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Yeung TM Chia LA Kosinski CM Kuo CJ 《Cellular and molecular life sciences : CMLS》2011,68(15):2513-2523
The gastrointestinal epithelium is a highly organised tissue that is constantly being renewed. In order to maintain homeostasis,
the balance between intestinal stem cell (ISC) self-renewal and differentiation must be carefully regulated. In this review,
we describe how the intestinal stem cell niche provides a unique environment to regulate self-renewal and differentiation
of ISCs. It has traditionally been believed that the mesenchymal myofibroblasts play an important role in the crosstalk between
ISCs and the niche. However, recent evidence in Drosophila and in vertebrates suggests that epithelial cells also contribute to the niche. We discuss the multiple signalling pathways
that are utilised to regulate stemness within the niche, including members of the Wnt, BMP and Hedgehog pathways, and how
aberrations in these signals lead to disruption of the normal crypt–villus axis. Finally, we also discuss how CDX1 and inhibition
of the Notch pathway are important in specifying enterocyte and goblet cell differentiation respectively. 相似文献
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夏海峰 《淮阴师范学院学报(自然科学版)》2002,1(4):14-16
本文指出仪洪勋和Brosch G在具有三个判别的CM公共值的亚纯函数的唯一性定理中,关于对数函数的导数是整函数的推导,可以用指数函数求导的方法来证明.改进了仪洪勋和Brosch G关于重值与唯一性定理. 相似文献
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Pain relief by xenograft of subarachnoid microencapsulated bovine chromaffin cells in cancer patients 总被引:5,自引:0,他引:5
XUE Yilong HE Limin LI Liushu WANG Jie WANGZhenfu LI Xinjian ZHANG Li CM Xin ZHU Jianhu LUOYun ZHONG Daguang LI Yanling 《自然科学进展(英文版)》2000,10(12):919-924
The bovine chromaffin cells (BCC) implanted into the subarachnoid space can release analgesic
substances such as opioid peptides and ealeeholamines. Clinical trials have provided the evidence that the implantation of polyvinylchloride ( PVC) hollow fiber encapsulated BCC by surgery can relief the pain in cancer patients. In the present study, BCC were encapsulated in alginate-polylysine-alginate (APA) mieroencapsules which protect the grafting of xenogeneic cells from host immune system anil allow BCC to function effectively without using immunosuppression agents. The microencapsulated BCCs (5 X 106~—8 X 106) were transplanted into the subarachnoid space I^._s of 17 patients who suffered from chronic cancer pain and had to have long-term administration of analgesics. The pain scores and morphine intake tesl showed that microencapsulated BCC graft totally stopped the chronic pain in three of the patients over a period of 200 days and in the other three over a period of 100 days. The resulls suggesl thai APA microencapsulated BCC xenotransplantation could be a novel alternative approach to managing pain of cancer patients. 相似文献
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