A Study of the Behaviour of Denim Cloth Made from Modified Rotor Spun Yarn

This paper described the physical behaviour of three types of denim cloths produced from rotor yarn, ring yarn and modified rotor yarn (prepared by adding conventional twist to rotor yarn) respectively. Experimental work showed that denim cloth produced from the modified rotor yarn has superior properties over conventional rotor yarn in terms of surface texture and appearance,tearing strength and resistance to abrasion.     

一类矩阵方程的反对称正交反对称解及其最佳逼近

定义了一种新的矩阵类：反对称正交反对称矩阵,研究了一类矩阵方程的反对称正交反对称解的存在性及其最佳逼近问题。利用矩阵的广义奇异值分解,得到了该矩阵方程有反对称正交反对称解的充要条件及其通解表达式,并且给出了矩阵方程的解集合中与给定矩阵的最佳逼近。     

大型水利水电工程建设项目动态联盟组织模式的结构集成

针对大型水利水电工程建设项目的特点, 从特征结构、框架结构、动态结构等方面研究大型水利水电工程建设项目动态联盟组织模式的结构, 进行动态联盟组织的结构设计. 应用集成管理思想, 对动态联盟组织模式进行结构集成, 从结构框架、结构支撑、结构连接、结构评价等方面进行阐述. 运用模糊综合评判与神经网络评价集成方法对大型水利水电动态联盟组织结构进行评价.     

一种改进的基于博弈树模型的五子棋系统

通过对五子棋算法的研究,本文探讨了知识抽象、知识表示、估价函数、博弈树及搜索策略等人工智能领域的问题,并基于博弈树模型设计了一个智能五子棋系统。该系统采用多链表结构的知识表示方法记录棋局信息,可以全面地描述和分析棋局形势。最后,结合局部性原理,采取增量分析法、α-β剪枝及低层剪枝等手段加速分析和搜索效率,提高了该系统的反应速度和智能化程度。     

专家系统在液压回路设计中的应用

文章主要研究的是一种基于知识库的专家系统在液压回路设计中的应用,该系统通过对用 户输入的数据进行分析和推理,把设计的结果以设计图的形式输出。     

CCN蛋白家族研究进展

CCN蛋白家族包含多个成员,它们结构相似,富含半胱氮酸。作为分泌蛋白,CCN蛋白能够促进细胞生长、细胞粘附、细胞迁移;诱导细胞凋亡;并调控肿瘤生长、血管发生和软骨内骨化。由于CCN蛋白在癌症和其它疾病预测或／和诊断中的重要性,成为近几年研究的热点。本文将简述近几年在CCN蛋白领域的研究进展。     

Rapid reversion of aging phenotypes by nicotinamide through possible modulation of histone acetylation

Aging appears to be an irreversible process. Here we report that nicotinamide (NAA) can induce rapid and reversible reversion of aging phenotypes in human diploid fibroblasts in terms of cell morphology and senescence-associated β-galactosidase activity. Although NAA seems to enhance the replicative potential of the cells, it has little effect on their growth rate and life span, suggesting that NAA action is rather separated from the cellular replicative system. The effects are unique to NAA: none of the NAA-related compounds examined (an NAD precursor/niacin, NAD analogs, and poly(ADP-ribose) polymerase inhibitors) exerted similar effects. Thus, NAD-related metabolism and poly(ADP-ribosyl)ation are unlikely related to the NAA action. On the other hand, histone acetyltransferase (HAT) activity was elevated in NAA-exposed cells, while in aged cells, HAT activity and histone H4 acetylation were lowered. Taken together, the results suggest that NAA may cause rejuvenation by restoring, at least in part, altered gene expression in aged cells through its activation of HAT. Received 27 August 2001; received after revision 15 October 2001; accepted 15 October 2001     

采用计算机数据处理的表面形貌分析方法及应用

本文对两种形貌检测和评定方法进行了对比分析,报告了用计算机进行数据处理的三维形貌分析方法对铝板深拉延中的着磨损故障等问题进行的试验研究和分析结果.指出:选择更符合摩擦学要求的表面形貌(如用激光进行表面处理的轧辊轧制的铝板)可显著改善铝板深拉延中的摩擦和润滑性能,从而改善铝板的拉延性能.     

HIV-1复合多表位基因的原核表达和多克隆抗体制备

为表达HIV-1复合多表位基因并制备其多克隆抗体.设计引物,以HIV-1标准株全长cDNA序列为模板,PCR扩增获得p24基因片段;合成改造后的多个表位基因MEG并且与p24片段相连接,克隆入大肠杆菌.将测序正确的p24MEG基因克隆入原核表达载体pET32a并诱导表达.采用Ni2 -NTA亲和柱纯化目的蛋白,以p24抗体对纯化蛋白进行Western-blot分析.将纯化的融合蛋白免疫家兔制备多克隆抗体.通过PCR成功获得长度为651 bp的HIV-1的p24片段,获得了与多表位基因连接后的p24MEG基因,通过诱导表达,显示在相对分子量约45 000处有预计大小的特异性条带,表明成功表达出融合蛋白.经此纯化的融合蛋白免疫的家兔能产生特异性抗体,其滴度达到1:3 200.纯化的融合蛋白和多克隆抗体为研究新型HIV疫苗奠定一定的理论和实践基础.     

Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus

Type 2 or non-insulin-dependent diabetes mellitus (NIDDM) is the most common form of diabetes worldwide, affecting approximately 4% of the world's adult population. It is multifactorial in origin with both genetic and environmental factors contributing to its development. A genome-wide screen for type 2 diabetes genes carried out in Mexican Americans localized a susceptibility gene, designated NIDDM1, to chromosome 2. Here we describe the positional cloning of a gene located in the NIDDM1 region that shows association with type 2 diabetes in Mexican Americans and a Northern European population from the Botnia region of Finland. This putative diabetes-susceptibility gene encodes a ubiquitously expressed member of the calpain-like cysteine protease family, calpain-10 (CAPN10). This finding suggests a novel pathway that may contribute to the development of type 2 diabetes.