Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus |
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Authors: | Horikawa Y Oda N Cox N J Li X Orho-Melander M Hara M Hinokio Y Lindner T H Mashima H Schwarz P E del Bosque-Plata L Horikawa Y Oda Y Yoshiuchi I Colilla S Polonsky K S Wei S Concannon P Iwasaki N Schulze J Baier L J Bogardus C Groop L Boerwinkle E Hanis C L Bell G I |
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Institution: | Howard Hughes Medical Institute, The University of Chicago, Chicago, Illinois, USA. |
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Abstract: | Type 2 or non-insulin-dependent diabetes mellitus (NIDDM) is the most common form of diabetes worldwide, affecting approximately 4% of the world's adult population. It is multifactorial in origin with both genetic and environmental factors contributing to its development. A genome-wide screen for type 2 diabetes genes carried out in Mexican Americans localized a susceptibility gene, designated NIDDM1, to chromosome 2. Here we describe the positional cloning of a gene located in the NIDDM1 region that shows association with type 2 diabetes in Mexican Americans and a Northern European population from the Botnia region of Finland. This putative diabetes-susceptibility gene encodes a ubiquitously expressed member of the calpain-like cysteine protease family, calpain-10 (CAPN10). This finding suggests a novel pathway that may contribute to the development of type 2 diabetes. |
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