Prediction of the structure of a receptor-protein complex using a binary docking method.

To validate procedures of rational drug design, it is important to develop computational methods that predict binding sites between a protein and a ligand molecule. Many small molecules have been tested using such programs, but examination of protein-protein and peptide-protein interactions has been sparse. We were able to test such applications once the structures of both the maltose-binding protein (MBP) and the ligand-binding domain of the aspartate receptor, which binds MBP, became available. Here we predict the binding site of MBP to its receptor using a 'binary docking' technique in which two MBP octapeptide sequences containing mutations that eliminate maltose chemotaxis are independently docked to the receptor. The peptides in the docked solutions superimpose on their original positions in the structure of MBP and allow the formation of an MBP-receptor complex. The consistency of the computational and biological results supports this approach for predicting protein-protein and peptide-protein interactions.     

Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease.

Transforming growth factor-beta 1 (TGF-beta 1) is a multifunctional growth factor that has profound regulatory effects on many developmental and physiological processes. Disruption of the TGF-beta 1 gene by homologous recombination in murine embryonic stem cells enables mice to be generated that carry the disrupted allele. Animals homozygous for the mutated TGF-beta 1 allele show no gross developmental abnormalities, but about 20 days after birth they succumb to a wasting syndrome accompanied by a multifocal, mixed inflammatory cell response and tissue necrosis, leading to organ failure and death. TGF-beta 1-deficient mice may be valuable models for human immune and inflammatory disorders, including autoimmune diseases, transplant rejection and graft versus host reactions.     

混合氯化稀土催化合成DOP,DOM和DOA

本文报道:价廉的混合氯化稀土,对合成DOP等增塑剂有明显的催化效果。产品精制简单,转化率高,有应用前景。     

求Ramsey数最优下界值的递归算法

要确定每个具体的Ramsey数的数值是相当困难的,至今人们只求出了为数很少的几个Ramsey数的数值.人们在研究Ramsey数性质的同时,也在估计Ramsey数的数值,得出了某些Ramsey数的下界值,但工作进展缓慢.本文提出了一种计算Ramsey数最优下界值的递归算法,该算法利用当今关于Ramsey数的最新结果,能得出Ramsey数的目前最优下界值.1 算法描述不妨将本算法定名为G,参数个数为1个以上(可变化),算法允许递归调用,其输出值为Ramsey数的目前最优下界值.C(k_1,k_2…,k_n)表示以k_1,k_2…,k_n作为输入,通过算法G所得到的输出结果,即C(k_1,k_2…,k_n)表示的是G算出的Ramsey数N(k_1,k_2,…,k_n;2)的目前最优下界值,其中N(k_1,k_2…,k_n;2)的含意与文献[2]中有关含意相同.算法G:     

用栅板剪切干涉法确定应力强度因子

本文介绍了一种用栅板剪切干涉法确定应力强度因子的新方法,阐明了该方法的基本原理与实验技术,通过三点弯曲梁确定了Ⅰ型裂纹应力强度因子,实验结果与理论上近似计算结果相符合。     

锁具装箱方案

讨论了锁具装箱问题，首先用穷举法统计符合要求的一批锁具的数量，然后根据奇数和偶数的转换关系，给出装箱的销售方案。应用本方法比较完满地解决了锁具装箱问题，而且经过简单改动，可以进行推广。     

有限水深慢船理论及波阻计算

本文推广E.Baba的无限水深慢船理论,建立了有限水深慢船理论.基于低速与量级假定,将总速度势Φ分为合模势(?)_r和波动势(?),分别给出了各自的表达式,进而推导了有限水深兴波的波高、波阻公式.编制了波阻计算程序,并以半浸圆球为例进行验算,计算了Series 60船型在8种水深时的波阻.理论分析和数值计算表明:当水深趋于无穷时,本理论与Baba理论是一致的.     

电镀添加剂的NMR定量分析

本文叙述了用于定量分析电镀添加剂中丙烯磺酸钠和糖精钠的快速、准确、精密的ＮＭＲ分析方法．该方法是依据每个组分的ＮＭＲ特征信号和用作内标的四甲基澳化按ＮＭＲ信号的积分比值建立的，各组分不需要预先分离．     

矿石可选性预测专家系统(Ⅰ)─—系统的总体设计

建立了铅锌矿石可造性预测专家系统，运行结果良好。本篇着重论述矿石可造性领域知识的特点和知识表示方法；分析矿石可造性预测专家系统的主要特征；讨论矿石可造性预测子问题的划分、一般决策过程、推理控制策略以及系统的总体设计。