左西孟旦对老年慢性心衰失代偿期患者TNFα和NT-proBNP水平的影响

目的现察左西孟旦对老年慢性心衰失代偿期患者血清中的肿瘤坏死因子(Tumor Necrosis Factor-alpha,TNF-α)和氮基末端B型利钠肽前体(Amino Terminal pro-B-type Natriuretic Peptide Precursor,NT-pro BNP)水平的影响.方法慢性心力衰竭患者96例,随机分为2组,46例常规治疗组,50例左西孟旦组,并选同期正常体检者40例为对照组.结果治疗前,两个组别的心脏彩超指标无显著差异(P0.05),治疗后,两个组别的心脏指标有不同程度的改善(P0.05),与常规治疗组相比,左西孟旦组的心脏指标改善明显(P0.05),与对照组相当(P0.05).与对照组相比,两组慢性心衰病患的TNF-α和NT-pro BNP明显增高(P0.05),治疗前两组慢性心衰病患的TNF-α和NT-pro BNP无显著差异(P0.05),治疗后两组慢性心衰病患的TNF-α和NT-pro BNP均明显降低(P0.05),但与常规治疗组相比,左西孟旦组的TNF-α和NT-pro BNP降低明显(P0.05).与常规治疗组比,左西孟旦组的呼吸困难评分降低明显(P0.05).两个组别均无明显不良反应.结论左西孟旦对慢性心衰患者预后有较好的改善作用,进一步的机制还需深入研究.     

慢性心衰患者血浆BNP检测的临床价值相关研究

目的:探讨慢性心衰(CHF)患者血浆脑钠肽(BNP)检测的临床价值.方法:采用荧光免疫分析对101例CHF患者及45例健康对照者进行血浆BNP测定,同时以彩色多普勒超声心动仪测定CHF患者左心室舒张末期内径(LVEDD)、左心室射血分数(LVEF),并与血浆BNP水平作相关性分析,并对治疗心衰前后患者BNP水平作对比分析.结果:CHF组患者血浆BNP水平明显高于健康对照者(P＜0.01);不同心功能级别之间BNP值差异有统计学意义;心衰患者血浆BNP水平与NYHA、LVEDD、LVEF有明显相关性.结论:BNP是评价CHF患者心室功能的灵敏指标,BNP的检测在慢性心衰的诊断及治疗中具有较高的临床价值.     

钙拮抗剂对高血压并左室肥厚患者的血浆脑钠素的影响

目的:研究长效钙拮抗剂治疗高血压并左室肥厚对血浆脑钠素(BNP)的影响,为临床选择降压药提供更客观的依据.方法:①比较原发性高血压并左室肥厚、无左室肥厚及健康对照组BNP浓度的差别;②选择左室肥厚组作为随访对象,予以长效钙拮抗剂治疗(6±3)月,比较BNP、左室质量指数(LVMI)在治疗前后的变化.结果:①高血压并左室肥厚组血浆BNP水平显著高于高血压无左室肥厚组和健康对照组(P＜0.001);②高血压患者血浆BNP与LVMI呈正相关关系(相关系数r=0.551,P＜0.001);③使用长效钙拮抗剂治疗高血压并左室肥厚患者(6±3)个月,血浆BNP水平和LVMI均显著降低(P＜0.001).结论:长效钙拮抗剂治疗高血压并左室肥厚患者能显著降低患者BNP水平,能够逆转左室肥厚.     

比较氨氯地平和硫氮卓酮缓释片对高血压病患者动态血压的影响

目的:比较氨氯地平(络活喜)和硫氮卓酮缓释片(合贝爽)对高血压病患者动态血压的影响.方法:选取60例高血压病患者,分别用氨氯地平(5mg qd,n=30)、硫氮卓酮缓释片(90mg qd,n=30)治疗8周,观察治疗前后动态血压值的变化.结果:(1)氨氯地平组和硫氮卓酮缓释片组服药前后(8周末)的24小时、白昼和夜间的平均收缩压、舒张压均明显下降(P均＜0.05).24h、白昼和夜间的平均收缩压/舒张压下降值在氨氯地平组则分别为(10.5±2.0)/(7.3±1.8),(12.8±1.9)/(8.1±1.6),(9.9±1.8),(6.2±1.4)mmHg,(P＜0.05);在硫氮卓酮缓释片组分别为(8.7±2.5)/(5.6±2.6),(10.3±2.5)/(6.3±2.2),(6.9±1.9)/(5.4±2.3)InmHg.(P＜0.05),两组间上述指标比较无显著性差异(P＞0.05),但动态心率指标硫氮卓酮缓释片组明显低于氨氯地平组.(2)谷峰比:硫氮卓酮缓释片组和氨氯地平组SBP分别为55%、78%;DBP分别为57%、72%.结论:硫氮卓酮缓释片(90mg/d)和氨氯地平(5mg/d)一样均可以维持24小时平稳降压.     

苓桂术甘汤合葶苈大枣泻肺汤治疗慢性心衰（痰饮阻肺型）临床疗效观察

观察苓桂术甘汤合葶苈大枣泻肺汤治疗慢性心衰(痰饮阻肺型)疗效。将2018年5月1日至2019年5月1日甘肃省中医院心血管病科收治的40例慢性心衰患者随机分成2组,对照组20例采取常规的西医治疗,治疗组20例在西医常规治疗基础上加用苓桂术甘汤合葶苈大枣泻肺汤加减治疗,两组治疗均以4周为1个疗程,共观察2个疗程。治疗前后,均关注患者的中医证候变化及脑钠肽前体(NT-pro BNP)水平,根据症状变化判定心功能分级。两组患者治疗后心功能疗效的总有效率,治疗组总有效率90.00%,对照组总有效率75.00%,治疗组疗效显著优于对照组,差异具有统计学意义(P=0.0360.05)。两组患者治疗后中医症候疗效的总有效率,治疗组总有效率90.00%,对照组总有效率70.00%,治疗组疗效显著优于对照组,差异具有统计学意义(P=0.0310.05)。两组患者治疗后血清中NT-pro BNP的水平均有所降低,且治疗组中治疗后血清中的NT-pro BNP水平明显低于对照组,经治疗后均有疗效,两组P0.05。苓桂术甘汤合葶苈大枣泻肺汤加减治疗痰饮阻肺型慢性心力衰竭效果明显,可于辨证正确的情况下广泛应用于临床。     

左旋卡尼汀治疗对维持性血透病人左心室肥厚的影响

目的：研究静脉注射左旋卡尼汀对维持性血透病人左心室肥厚的影响。方法：将50例尿毒症患者随机分为两组。治疗组24例于血透后予以左旋卡尼汀2.0g静脉推注共6月;对照组26例不用,其它治疗两组相同。治疗前后观察左室舒张末期内径LVDd、左室收缩末期内径LVDs、左房内径LAD、室间隔厚度IVST和左室后壁厚度PWT变化。结果：治疗前两组各项指标均无差异,但均明显高于正常值或处于正常值高限,治疗组3月后各项指标较治疗前有所降低,其中左室收缩末期内径LVDs显著下降（P〈0.05）,治疗6月后各项指标均明显下降（P〈0.01）,而对照组治疗3月、6月后上述指标无明显改变。结论：左旋卡尼汀能改善维持性血透患者的左心室肥厚。此作用可能与其加强心肌收缩力,改善心脏功能有关。     

重组人B型利钠肽治疗扩张型心肌病心力衰竭患者临床效果

目的:分析研讨重组人B型利钠肽(rhBNP)治疗扩张型心肌病心力衰竭患者的临床效果.方法:回顾性分组讨论94例患者(扩张型心肌病心力衰竭疾病),均为我院2015年6月~2016年7月期间收治的住院患者,分组后区分两组治疗方式,47例对照组(静脉滴注米力农药物)和47例研究组(重组人B型利钠肽治疗),观察各患者治疗状况,并对比分析.结果:研究组总疗效93.62%高于对照组78.72%,组间数据有统计学意义(P0.05).对比两组患者尿量变化、动脉压、心率指数,治疗前组间数据无统计学意义(P0.05);治疗后,研究组优于对照组,组间数据有统计学意义(P0.05).对比两组患者血浆BNP、心功能指数,治疗前组间数据无统计学意义(P0.05);治疗后,左室舒张末经(LVEDd)指数无统计学意义(P0.05),但研究组血浆脑钠素(BNP)、左室射血分数(LVEF)指数均优于对照组,组间数据有统计学意义(P0.05).结论:重组人B型利钠肽在治疗扩张型心肌病心力衰竭疾病上,疗效突出,患者心率、动脉压、尿量,以及血浆BNP等指数均得到显著改善,值得进一步推广.     

酒石酸美托洛尔对扩张型心肌病患者的作用效果分析

探究酒石酸美托洛尔对扩张型心肌病患者的作用效果。选取2019年3月-2020年4月河西学院附属张掖人民医院收治的扩张型心肌病患者81例,经由随机数字表分为2组,对照组(40例)采用常规治疗,研究组(41例)在常规治疗基础上给予酒石酸美托洛尔治疗,对比2组临床疗效、心功能指标、血浆B型钠尿肽(BNP)及运动耐量。研究组总有效率95.12%高于对照组75.00%(P0.05);治疗后研究组LVDs、LVDd低于对照组,CO高于对照组,差异有统计学意义(P0.05);治疗后2组心率及BNP均较治疗前下降,研究组低于对照组(P0.05);治疗后研究组6MWT(417.42±61.30)m大于对照组(388.65±63.74)m,差异有统计学意义(P0.05)。酒石酸美托洛尔治疗扩张型心肌病效果确切,可改善患者心功能,降低血浆BNP水平,提高运动耐力,改善生活质量。     

吲达帕胺联合氨氯地平在高血压合并冠心病治疗中的作用分析

探究吲达帕胺联合氨氯地平在高血压合并冠心病治疗中的作用。选取2018年3月～2019年8月武威市人民医院收治的高血压合并冠心病患者125例,采用随机对照组实验设计,随机数字表法分为观察组与对照组,对照组采用氨氯地平治疗,观察组在给予吲达帕胺联合氨氯地平,对比2组患者治疗总有效率、血压水平及心功能。观察组治疗总有效率95.31%高于对照组83.61%,差异有统计学意义(P0.05);治疗后,将2组患者收缩压、舒张压比较,均低于治疗前,且观察组较对照组低,存在显著性差异(P0.05);治疗后,2组患者LVEF较治疗前升高,观察组高于对照组(P0.05);2组患者LVEDD、LVESD较治疗前降低,观察组低于对照组,存在显著性差异(P0.05);2组患者不良反应发生率比较差异无统计学意义(P0.05)。吲达帕胺联合氨氯地平治疗高血压合并冠心病疗效确切,且可改善患者心功能,安全性较高。     

左旋甲状腺素治疗亚临床甲减的效果和对血脂的影响评价

分析左旋甲状腺素治疗亚临床甲减疗效.选取88例亚临床甲减患者为本次研究对象,病例均为2018年11月-2019年10月就诊患者.以随机、单盲法分组,观察组和对照组各44例.实施常规治疗患者纳入对照组,增加左旋甲状腺素治疗患者纳入观察组.对比分析两组治疗效果及对患者甲状腺功能、血脂、心功能的影响.观察组治疗有效率为95.45％,对照组为81.82％,观察组更高(P＜0.05).观察组治疗后TSH水平明显降低,FT4、FT3水平明显升高,且指标改善幅度高于对照组(P＜0.05).观察组治疗后LDL-C、TC、TG等血脂水平有明显降低且降低幅度高于对照组(P＜0.05).观察组治疗后LVEDD、LVESD两项心功能指标显著降低,观察组降低幅度高于对照组(P＜0.05),观察组LEVF指标明显降低,且降低幅度高于对照组(P＜0.05).左旋甲状腺素应用于亚临床甲减的治疗,可有效改善患者TSH指标,促进血脂指标恢复正常.     

Markedness and its Interpretation in Language Use

Language markedness is a common phenomenon in languages, and is reflected from hearing, vision and sense, i.e. the variation in the three aspects such as phonology, morphology and semantics. This paper focuses on the interpretation of markedness in language use following the three perspectives, i.e. pragmatic interpretation, psychological interpretation and cognitive interpretation, with an aim to define the function of markedness.     

Features of Women's language

Language is a means of verbal communication. People use language to communicate with each other. In the society, no two speakers are exactly alike in the way of speaking. Some differences are due to age, gender, statue and personality. Above all, gender is one of the obvious reasons. The writer of this paper tries to describe the features of women＇s language from these perspectives： pronunciation, intonation, diction, subjects, grammar and discourse. From the discussion of the features of women＇s language, more attention should be paid to language use in social context. What＇s more, the linguistic phenomena in a speaking community can be understood more thoroughly.     

Characterization of Ordovician carbonate reservoirs, southeastern Saskatchewan, Canada

The discovery of the prolific Ordovician Red River reservoirs in 1995 in southeastern Saskatchewan was the catalyst for extensive exploration activity which resulted in the discovery of more than 15 new Red River pools. The best yields of Red River production to date have been from dolomite reservoirs. Understanding the processes of dolomitization is, therefore, crucial for the prediction of the connectivity, spatial distribution and heterogeneity of dolomite reservoirs.The Red River reservoirs in the Midale area consist of 3～4 thin dolomitized zones, with a total thickness of about 20 m, which occur at the top of the Yeoman Formation. Two types of replacement dolomite were recognized in the Red River reservoir: dolomitized burrow infills and dolomitized host matrix. The spatial distribution of dolomite suggests that burrowing organisms played an important role in facilitating the fluid flow in the backfilled sediments. This resulted in penecontemporaneous dolomitization of burrow infills by normal seawater. The dolomite in the host matrix is interpreted as having occurred at shallow burial by evaporitic seawater during precipitation of Lake Almar anhydrite that immediately overlies the Yeoman Formation. However, the low δ18O values of dolomited burrow infills (-5.9‰～ -7.8‰, PDB) and matrix dolomites (-6.6‰～ -8.1‰, avg. -7.4‰ PDB) compared to the estimated values for the late Ordovician marine dolomite could be attributed to modification and alteration of dolomite at higher temperatures during deeper burial, which could also be responsible for its 87Sr/86Sr ratios (0.7084～0.7088) that are higher than suggested for the late Ordovician seawaters (0.7078～0.7080). The trace amounts of saddle dolomite cement in the Red River carbonates are probably related to "cannibalization" of earlier replacement dolomite during the chemical compaction.     

低渗透非均质砂岩油藏启动压力梯度研究

理论推导与室内实验相结合,建立了低渗透非均质砂岩油藏启动压力梯度确定方法。首先借助油藏流场与电场相似的原理,推导了非均质砂岩油藏启动压力梯度计算公式。其次基于稳定流实验方法,建立了非均质砂岩油藏启动压力梯度测试方法。结果表明:低渗透非均质砂岩油藏的启动压力梯度确定遵循两个等效原则。平面非均质油藏的启动压力梯度等于各级渗透率段的启动压力梯度关于长度的加权平均;纵向非均质油藏的启动压力梯度等于各渗透率层的启动压力梯度关于渗透率与渗流面积乘积的加权平均。研究成果可用于有效指导低渗透非均质砂岩油藏的合理井距确定,促进该类油藏的高效开发。     

On Tragic Consciousness In The Works By Ernest Hemingway

As an American modern novelist who were famous in the literary world, Hemingway was not a person who always followed the trend but a sharp observer. At the same time, he was a tragedy maestro, he paid great attention on existence, fate and end-result. The dramatis personae's tragedy of his works was an extreme limit by all means tragedy on the meaning of fearless challenge that failed. The beauty of tragedy was not produced on the destruction of life, but now this kind of value was in the impact activity. They performed for the reader about the tragedy on challenging for the limit and the death.     

A computer generator for randomly layered structures

AcomputergeneratorforrandomlylayeredstructuresYUJia shun1,2,HEZhen hua2(1.TheInstituteofGeologicalandNuclearSciences,NewZealand;2.StateKeyLaboratoryofOilandGasReservoirGeologyandExploitation,ChengduUniversityofTechnology,China)Abstract:Analgorithmisintrod…     

An Index mechanism for multi-scale view in spatial databases

There are numerous geometric objects stored in the spatial databases. An importance function in a spatial database is that users can browse the geometric objects as a map efficiently. Thus the spatial database should display the geometric objects users concern about swiftly onto the display window. This process includes two operations:retrieve data from database and then draw them onto screen. Accordingly, to improve the efficiency, we should try to reduce time of both retrieving object and displaying them. The former can be achieved with the aid of spatial index such as R-tree, the latter require to simplify the objects. Simplification means that objects are shown with sufficient but not with unnecessary detail which depend on the scale of browse. So the major problem is how to retrieve data at different detail level efficiently. This paper introduces the implementation of a multi-scale index in the spatial database SISP (Spatial Information Shared Platform) which is generalized from R-tree. The difference between the generalization and the R-tree lies on two facets: One is that every node and geometric object in the generalization is assigned with a importance value which denote the importance of them, and every vertex in the objects are assigned with a importance value,too. The importance value can be use to decide which data should be retrieve from disk in a query. The other difference is that geometric objects in the generalization are divided into one or more sub-blocks, and vertexes are total ordered by their importance value. With the help of the generalized R-tree, one can easily retrieve data at different detail levels.Some experiments are performed on real-life data to evaluate the performance of solutions that separately use normal spatial index and multi-scale spatial index. The results show that the solution using multi-scale index in SISP is satisfying.     

Jane Eyre——A Feminist In The 19th Century

In the 19th century the society was controlled by men, and women were just appendants of them, they had not any rights and freedom. But Jane was an exception, she showed some characteristics of early feminist. Jane showed her characteristics of feminism in three aspects: rebellion, equality, and independence. These characteristics were helpful to her success, and feminism is the only way out for women of that time.     

Achieving Unusual States of Matter Under High Pressure

正The periodicity of the elements and the non-reactivity of the inner-shell electrons are two related principles of chemistry,rooted in the atomic shell structure.Within compounds,Group I elements,for example,invariably assume the+1 oxidation state,and their chemical properties differ completely from those of the p-block elements.These general rules govern our understanding of chemical structures and reactions.Using first principles calcula-     

Exchange-Correlation and Electronic Excitation Energies from Pairing Matrix Fluctuations

We have developed an adiabatic connection to formulate the ground-state exchange-correlation energy in terms of pairing matrix linear fluctuations.This formulation of the exchange-correlation energy opens a new channel for density functional approximations based on the many-body perturbation theory.We illustrate the potential of such approaches with an approximation based on the particle-particle Random Phase Approximation(pp-RPA).This re-