HA、LN、PⅢNP、Ⅳ-C在肝纤维化诊断中的意义

目的:探讨血清透明质酸(HA),层粘连蛋白(LN),Ⅲ型前胶原(PCⅢ),Ⅳ型胶原(CⅣ)的测定在诊断肝纤维化中的意义。方法:采用放射免疫分析法分别对235例急、慢性肝炎,肝硬化,肝癌患者及46例健康人血清HA、LN、PCⅢ、Ⅳ-C检测,并进行了统计分析。结果:急慢性肝炎、肝硬化、肝癌的4项指标定量结果均高于对照组。结论:结合临床初步评价这四种1995年中华医学会《病毒性肝炎防治方案》推荐的肝纤维化指标在肝纤维化的诊断有较大意义。     

瘦素在肝纤维化中的作用探讨

目的观察慢性乙型肝炎患者血清瘦素(Leptin)与Ⅲ型前胶原(PCEE)、透明质酸(HA)、层粘连蛋白(LN)和肝脏纤维组织增长的关系.方法采用放射免疫吸附实验(RIA)测定105例慢性乙型肝炎、肝硬化患者血清瘦素、HA,LN,PCⅢ含量做定量分析.结果各型乙肝患者血清瘦素水平明显高于对照组(P<0.01或P<0.05).瘦素与血清HA,LN,PCⅢ呈正相关(P<0.01或P<0.05).结论慢性乙型肝炎、肝硬化患者血清瘦素水平明显升高,并与HA,LN,PCⅢ含量呈正相关.瘦素在慢性乙型肝炎肝纤维化发病机制中起一定作用.     

乙型肝炎患者血清肝纤维化指标与肝穿活检病理分期(S)相关性分析

寻找肝纤维化敏感可靠的血清学指标,分析血清肝纤四项浓度与肝脏不同程度纤维化病理分期的对应关系。回顾性分析78例慢性乙型肝炎肝穿刺病理活检病例结果及血清肝纤四项指标:透明质酸(HA)、Ⅲ型前胶原肽(PCⅢ)、Ⅳ型胶原(Ⅳ-C)、层黏连蛋白(LN)的水平。将肝纤四项与肝组织纤维化病理分期进行对照分析。HA、PCⅢ、Ⅳ-C、LN与肝组织纤维化病理分期的相关系数(r)分别为0.665(P0、01)、0.387(P0.05)、0.488(P0.05)、0.412(P0.05)。四个指标水平均随着肝组织纤维化程度的加重呈上升趋势且HA的S3、S4期水平与S1期、S4期水平与S1、S2、S3期比较差异有统计学差异(P0.05),PCⅢ的S3、S4期水平与S1期比较差异有统计学差异(P0.05)。以S0~S2为轻度纤维化,S3~S4为明显纤维化,通过ROC曲线分析HA、PCⅢ、Ⅳ-C、LN的曲线下面积分别为0.855、0.736、0.779、0.642。敏感度:LNⅣ-CPCⅢHA;特异性:HAPCⅢLNⅣ-C。肝纤四项与慢性乙型肝炎肝组织纤维化程度呈正相关性对肝组织明显纤维化时(S3、S4),临床诊断价值较大,其中LN最敏感,HA特意性最高。     

铁离子、铜离子及腐殖酸对壬基酚光降解的影响

在模拟日光辐射条件下,研究了内分泌干扰物壬基酚(NP)在腐殖酸(HA)、Fe(Ⅲ)、Cu(Ⅱ)及两种金属离子分别协同腐殖酸的络合体系下的光降解现象,探讨了腐殖酸浓度、Fe(Ⅲ)浓度、Cu(Ⅱ)浓度、光照时间等对NP光解的影响.研究结果表明:NP直接光降解率较低,加入低浓度HA时对NP光解有促进作用,HA浓度增大对NP光解起抑制作用,且随浓度增大抑制作用增强;Fe(Ⅲ)浓度越大,壬基酚的降解率越大;在相同的光照条件下,腐殖酸和铁的络合体系表现出更强的降解作用,降解能力依次为NP+HA+Fe(Ⅲ)NP+Fe(Ⅲ)NP+HANP.Cu(Ⅱ)低浓度时,对壬基酚光降解有促进作用;当Cu(Ⅱ)浓度超过0.3 mmol/L时,反而会削弱Cu(Ⅱ)对壬基酚光降解的促进作用;Cu(Ⅱ)在与腐殖酸共存时,会促进壬基酚的降解,降解能力依次为NP+HA+Cu(Ⅱ)NP+Cu(Ⅱ)NP+HANP.     

HA、LN、PⅢNP、IV-C在肝纤维化诊断中的意义

目的：探讨血清透明质酸（HA），层粘连蛋白（LN），Ⅲ型前胶原（PCⅢ），Ⅳ型胶原（CⅣ）的测定在诊断肝纤维化中的意义。方法：采用放射免疫分析法分别对235例急、慢性肝炎，肝硬化，肝癌患者及46例健康人血清HA、LN、PCⅢ、Ⅳ-C检测，并进行了统计分析。结果：急慢性肝炎、肝硬化、肝癌的4项指标定量结果均高于对照组。结论：结合临床初步评价这四种1995年中华医学会《病毒性肝炎防治方案》推荐的肝纤维化指标在肝纤维化的诊断有较大意义。     

奶油制备CT造影剂观察消化道出血的实验研究

目的:以奶油为主要原料制备一种胃肠道CT低密度造影剂,并研究其对消化道出血的诊断价值。方法:以可食用淡奶油为原料,添加少量瓜尔豆胶,经搅拌机搅打后制得低密度造影剂。在CT扫描图像上观察其均匀性并测量CT值、比较其与血凝块的密度差异;在离体猪小肠中以混入肝素的血浆0.1、0.2、0.4mL模拟微量的消化道出血,观察该低密度造影剂对出血灶的显示效果,并比较其与中性对比剂(水)对出血的显示效果。结果:制得的低密度造影剂的CT扫描图像较均匀,CT值范围为-500～-700 Hu,与血凝块的密度差异明显;其能准确地显示和区分0.1、0.2、0.4 mL的出血灶,相对于中性对比剂(水)对出血的显示具有明显的优势。结论:以奶油添加瓜尔豆胶制备的胃肠道CT低密度造影剂均匀性良好,可以准确地显示出血灶,相对于中性对比剂(水)对消化道出血的诊断更为优越,值得进一步在临床诊断中试用。     

蛛网膜下腔出血早期脑血管造影的护理

蛛网膜下腔出血 ( SAH)是由位于脑蛛网膜下腔的动脉破裂引起的 ,是神经科最常见的急症之一 ,其死亡率及致残率高。数字减影血管造影 ( DSA)对SAH的病因诊断具有重大意义。选择适当时机进行造影是关键。早期即发病后 3天内行脑 DSA可以早期作出病因诊断[1] 。早期病因手术根治治疗对防止再出血、降低死亡率和致残率都很有帮助。我科1 994年至 1 999年对 SAH患者早期行脑 DSA检查1 5例 ,现将蛛网膜下腔出血早期脑血管造影的护理体会总结如下。1　资料与方法1 .1　资料本组患者 1 5例 ,男 8例、女 7例 ,年龄 2 4～ 68岁。临床诊断和脑 …     

上消化道出血的内科救护

目的：归纳上消化道出血的病因，探索上消化道出血患者的有效护理方法和护理途径。方法：对152例上消化道出血患者的内科护理工作探讨。结果：通过密切观察、及时给药、防止继发感染，做好生活、心理护理，152例患者取得良好的护理和治疗效果。结论：上消化道出血患者整个治疗过程中，临床护理观察是，临床诊断治疗的科学根据。     

脑干出血的CT表现与临床分析

目的 研究脑干出血的CT诊断价值。方法 运用影像学CT检查。结果 脑干出血CT表现为脑干高密度出血及血肿影。结论 CT能确定出血部位和累及范围。     

上消化道出血的现代诊断与治疗

对上消化道出血的现代诊断方法和治疗措施作一综述。     

Markedness and its Interpretation in Language Use

Language markedness is a common phenomenon in languages, and is reflected from hearing, vision and sense, i.e. the variation in the three aspects such as phonology, morphology and semantics. This paper focuses on the interpretation of markedness in language use following the three perspectives, i.e. pragmatic interpretation, psychological interpretation and cognitive interpretation, with an aim to define the function of markedness.     

Lower Paleozoic oil relationships within Williston Basin, Canada

The Williston Basin is a significant petroleum province, containing oil production zones that include the Middle Cambrian to Lower Ordovician, Upper Ordovician, Middle Devonian, Upper Devonian and Mississippian and within the Jurassic and Cretaceous. The oils of the Williston Basin exhibit a wide range of geochemical characteristics defined as "oil families", although the geochemical signature of the Cambrian Deadwood Formation and Lower Ordovician Winnipeg reservoired oils does not match any "oil family". Despite their close stratigraphic proximity, it is evident that the oils of the Lower Palaeozoic within the Williston Basin are distinct. This suggests the presence of a new "oil family" within the Williston Basin. Diagnostic geochemical signatures occur in the gasoline range chromatograms, within saturate fraction gas chromatograms and biomarker fingerprints. However, some of the established criteria and cross-plots that are currently used to segregate oils into distinct genetic families within the basin do not always meet with success, particularly when applied to the Lower Palaeozoic oils of the Deadwood and Winnipeg Formation.     

An Analysis of Catherine＇s Character——Wuthering Heights

Wuthering Heights, Emily Bronte＇s only novel, was published in December of 1847 under the pseudonym Ellis Bell. The book did not gain immediate success, but it is now thought one of the finest novels in the English language. Catherine is the key character of this masterpiece, because everybody and everything center on her though she had a short life. We can understand this masterpiece better if we know Catherine well.     

Characterization of Ordovician carbonate reservoirs, southeastern Saskatchewan, Canada

The discovery of the prolific Ordovician Red River reservoirs in 1995 in southeastern Saskatchewan was the catalyst for extensive exploration activity which resulted in the discovery of more than 15 new Red River pools. The best yields of Red River production to date have been from dolomite reservoirs. Understanding the processes of dolomitization is, therefore, crucial for the prediction of the connectivity, spatial distribution and heterogeneity of dolomite reservoirs.The Red River reservoirs in the Midale area consist of 3～4 thin dolomitized zones, with a total thickness of about 20 m, which occur at the top of the Yeoman Formation. Two types of replacement dolomite were recognized in the Red River reservoir: dolomitized burrow infills and dolomitized host matrix. The spatial distribution of dolomite suggests that burrowing organisms played an important role in facilitating the fluid flow in the backfilled sediments. This resulted in penecontemporaneous dolomitization of burrow infills by normal seawater. The dolomite in the host matrix is interpreted as having occurred at shallow burial by evaporitic seawater during precipitation of Lake Almar anhydrite that immediately overlies the Yeoman Formation. However, the low δ18O values of dolomited burrow infills (-5.9‰～ -7.8‰, PDB) and matrix dolomites (-6.6‰～ -8.1‰, avg. -7.4‰ PDB) compared to the estimated values for the late Ordovician marine dolomite could be attributed to modification and alteration of dolomite at higher temperatures during deeper burial, which could also be responsible for its 87Sr/86Sr ratios (0.7084～0.7088) that are higher than suggested for the late Ordovician seawaters (0.7078～0.7080). The trace amounts of saddle dolomite cement in the Red River carbonates are probably related to "cannibalization" of earlier replacement dolomite during the chemical compaction.     

Design and analysis of generic LBS application developing platform

Location based services is promising due to its novel working style and contents.A software platform is proposed to provide application programs of typical location based services and support new applications developing efficiently. The analysis shows that this scheme is easy implemented, low cost and adapt to all kinds of mobile nework system.     

橡胶颗粒沥青混合料低温抗裂性试验研究

以AC-13级配为基础,将橡胶颗粒代替部分集料掺入混合料中,以低温弯曲试验为评价方法对不同橡胶颗粒掺量下沥青混合料的低温抗裂性进行研究,并引入应变能密度值对混合料的低温抗裂性进行综合评价.试验结果表明:橡胶颗粒沥青混合料试件的破坏微应变均超过2 300,满足冬寒区的技术指标;无论是否掺加橡胶颗粒,随着温度的下降,沥青混合料破坏时的最大弯拉强度增大,弯拉应变降低,劲度模量增大;弯曲应变能密度在胶粒掺量为1%左右时具有较大的弯曲应变能密度值,此时橡胶颗粒沥青混合料具有较好的低温抗裂性.     

低渗透非均质砂岩油藏启动压力梯度研究

理论推导与室内实验相结合,建立了低渗透非均质砂岩油藏启动压力梯度确定方法。首先借助油藏流场与电场相似的原理,推导了非均质砂岩油藏启动压力梯度计算公式。其次基于稳定流实验方法,建立了非均质砂岩油藏启动压力梯度测试方法。结果表明:低渗透非均质砂岩油藏的启动压力梯度确定遵循两个等效原则。平面非均质油藏的启动压力梯度等于各级渗透率段的启动压力梯度关于长度的加权平均;纵向非均质油藏的启动压力梯度等于各渗透率层的启动压力梯度关于渗透率与渗流面积乘积的加权平均。研究成果可用于有效指导低渗透非均质砂岩油藏的合理井距确定,促进该类油藏的高效开发。     

Quantitative trait loci （QTLs） for quality traits related to protein and starch in wheat

Quality traits in wheat （Triticum aestirum L.） were studied by quantitative trait locus （QTL） analysis in a recombinant inbred line （RIL） population, a set of 131 lines derived from Chuan 35050 × Shannong 483 cross （ChSh）. Grains from RILs were assayed for 21 quality traits related to protein and starch. A total of 35 putative QTLs for 19 traits with a single QTL explaining 7.99-40.52% of phenotypic variations were detected on 10 chromosomes, 1D, 2A, 2D, 3B, 3D, 5A, 6A, 6B, 6D, and 7B. The additive effects of 30 QTLs were positive, contributed by Chuan 35050, the remaining 5 QTLs were negative with the additive effect contributed by Shannong 483. For protein traits, 15 QTLs were obtained and most of them were located on chromosomes 1 D, 3B and 6D, while 20 QTLs for starch traits were detected and most of them were located on chromosomes 3D, 6B and 7B. Only 7 QTLs for protein and starch traits were co-located in three regions on chromosomes 1D, 2A and 2D. These protein and starch trait QTLs showed a distinct distribution pattern in certain regions and chromosomes. Twenty-two QTLs were clustered in 6 regions of 5 chromosomes. Two QTL clusters for protein traits were located on chromosomes 1D and 3B, respectively, three clusters for starch traits on chromosomes 3D, 6B and 7B, and one cluster including protein and starch traits on chromosome 1D.     

On Tragic Consciousness In The Works By Ernest Hemingway

As an American modern novelist who were famous in the literary world, Hemingway was not a person who always followed the trend but a sharp observer. At the same time, he was a tragedy maestro, he paid great attention on existence, fate and end-result. The dramatis personae's tragedy of his works was an extreme limit by all means tragedy on the meaning of fearless challenge that failed. The beauty of tragedy was not produced on the destruction of life, but now this kind of value was in the impact activity. They performed for the reader about the tragedy on challenging for the limit and the death.     

The Analects and the Moment in Peking——The influence of a Confucian education system on the personality formation,the way of thinking and the fate of the main characters

0.Preface China has long been boasting of its colorful and immense culture which comprises of Taoism,Confucianism and Buddhism.The interwoven influence among the religions on Chinese way of thinking,on the nation＇s behavior in their social life throughout the long history is beyond list.