共查询到18条相似文献,搜索用时 625 毫秒
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干细胞移植是目前治疗器官损伤、神经退行性疾病研究的热点,国内外学者分别对神经干细胞、胚胎干细胞等进行了探索,渴望从中找出细胞移植领域的候选细胞,但是这些细胞大多面临着伦理、来源、免疫排斥等多方面的问题.然而,近年来发现的骨髓间充质干细胞在一定程度上弥补了这一不足.骨髓间充质干细胞凭借其多向分化潜能、强大的自我复制能力和可移植性,成为细胞移植、基因治疗中重要的候选细胞.骨髓间充质干细胞移植为器官损伤、神经退行性疾病的临床治疗带来了新的希望,本文对其生物学特性及临床应用方面做一综述. 相似文献
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周长梅 《淮北煤炭师范学院学报(自然科学版)》2006,27(4):45-48
由于干细胞具有自我更新和多向分化潜能的功能,使得人们用干细胞治疗多种疾病成为可能.就干细胞的研究概况、研究技术、干细胞技术的市场前景以及干细胞研究面临的问题等作一概述. 相似文献
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中国干细胞研究的现状、挑战和机遇 总被引:1,自引:0,他引:1
干细胞研究是过去十年中生物医学研究中最为热门的领域之一。我国的干细胞研究取得了很大的进步,同时也遇到不少问题。本文回顾了过去几年中我国干细胞研究的发展情况,从科研投入、硬件建设、人才队伍、科研成果、公共资源、法律法规、伦理准则、知识产权等多个方面,对我国干细胞研究的现状、面临的机遇和挑战进行了思考和分析,旨在对我们的工作有一个清醒的认识,以便能更好地部署我们下一步的工作。 相似文献
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本文主要对体细胞核移植技术和诱导多功能干细胞技术的具体操作过程、两种技术当前面临的问题以及他们的应用前景进行了简要说明. 相似文献
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造血干细胞的研究进展 总被引:4,自引:0,他引:4
白旭华 《内蒙古民族大学学报(自然科学版)》2004,19(4):422-424
干细胞是一类具有自我更新、高度增殖和多向分化潜能的原始细胞.造血干细胞在胚胎时期的发生、发育过程已得到进一步阐明.造血干细胞的移植已成功的应用于治疗多种血液系统和相关系统疾病.作者对造血干细胞的来源、细胞表面标志和其临床应用前景进行了综述. 相似文献
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干细胞及其应用 总被引:1,自引:0,他引:1
李朝霞 《盐城工学院学报(自然科学版)》2003,16(1):57-61
干细胞是当今细胞生物学乃至整个生命科学的主要热点之一,从干细胞的概念、生物学特性、分类等方面对干细胞进行了阐述,同时也对干细胞在移植治疗、克隆技术及转基因技术等方面的应用作了综述。 相似文献
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贺泽 《现代科技译丛(哈尔滨)》2004,(2):16-18
这段时间“干细胞”是一个很热的话题。作为一种治疗变异性失调的潜在特致药,干细胞受到广泛欢迎,但也引起一场政治争论。在美国,这方面的研究只取得了有限的进展。“成人干细胞和存在更多伦理问题的胚胎干细胞发挥相同的作用”这个声明成为这场政治争论的焦点。耶鲁大学医学研究者Diane Krause博士是成人干细胞研究的领头人之一,Robert Harris研究了这场争论背后的实质问题。 相似文献
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赵景春 《北京教育学院学报(自然科学版)》2008,3(4):14-20
干细胞是一类具有自我更新和多向分化潜能的细胞群体,它能长期地自我更新,在特定的条件下具有分化形成多种终末细胞的能力,不同来源的干细胞分化潜能各异。近年来干细胞的研究与应用几乎涉及到所有生命科学和生物医学领域。本文概述了干细胞的生物学特性和它的可塑性,综述了分离培养技术及其在基础研究和临床上应用的研究进展,最后,提出了问题和展望。 相似文献
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Recently, the study on "induced pluripotent stem cells" (iPS cells) has made a great breakthrough, and it is considered as a new milestone in the history of life science. This progress has updated our traditional concepts about pluripotency control, and provided people with a brand-new strategy for somatic cell nuclear reprogramming. In virtue of its availability and stability, this method holds great potential in both biological and clinical research. In order to introduce this rising field of study, this paper starts with an overview of the development of iPS cell establishment, describes the key steps in generating iPS cells, elaborates several relevant scientific issues, and evaluates its current restrictions and promises in future research. 相似文献
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涡虫成体干细胞研究进展 总被引:2,自引:0,他引:2
干细胞研究是当代生命科学研究的重点和热点之一,涡虫因具有结构简单、再生速度快、基因与脊椎动物同源性高等特点而成为研究再生的良好动物模型.涡虫的这种再生能力与其体内具有被称为neoblasts的多能干细胞群有关.文中结合近几年的研究成果从neoblasts与涡虫的再生关系、neoblasts的分子标记及研究方法3个方面进行综述,以促进neoblasts的研究. 相似文献
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杨林 《大理学院学报:综合版》2006,5(10):36-39
目的:探讨神经干细胞(NSCs)的诱导分化机制。方法:本文就Nscs的来源、分布、诱导分化的调控机制和因素以及其应用前景作一综述。结果:神经干细胞可从鼠、人的胚胎和成年中枢神经系统(CNS)成功分离并培养,具有自我更新和多分化潜能,经体外诱导或植入体内后均能分化为成熟神经元和神经胶质细胞。结论:神经干细胞的发现和研究的深入为神经发育研究及中枢神经功能重建提供了新的思路。 相似文献
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In 2006, an article published in Cell by Shinya Yamanaka took by surprise the stem cell research community. By performing
systematic retroviral transduction of factors enriched in embryonic stem (ES) cells, the authors demonstrated the reprogramming
of mouse fibroblasts into an ES cell-like state. These cells, baptized iPS (induced pluripotent stem) cells, were immediately
recognized as a ground-breaking discovery. Subsequently, the same authors and other groups reported a similar achievement
with human fibroblasts. Two years later, the number of top quality papers on iPS is astonishing, and interest in the scientific
community has risen to a fever pitch. But although iPS has the potential to revolutionize Regenerative Medicine, important
questions still remain unanswered. Work from multiple laboratories worldwide including ours is focused on deciphering the
molecular mechanisms of iPS, and trying to improve the technique to make it suitable for the clinic. In this review article
we briefly discuss the past, present and future of iPS, with emphasis on urgent issues to be solved.
Supported by the National Nature Science Foundation of China (Grant Nos. 30725012, 30630039 and 90813033), Knowledge Innovation
Project of Chinese Academy of Sciences (Grant No. KSCX2-YW-R-48), National Key Basic Research and Development Program of China
(Grant Nos. 2006CB701504, 2006CB943600, 2007CB948002, 2007CB947804. 2007CB947900) and Guangzhou Science and Technology Development
Funds (Grant No. 2008A1-E4011) 相似文献
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WANGYunfang PEIXuetao 《科学通报(英文版)》2003,48(13):1392-1396
In recent years, with the increasingly further studies on embryonic stem cells and the recognition of the biologic characteristics of adult stem cells, it has been discovered that adult stem cells have another phenomenon of “plasticity” in addition to the characteristics of strong potential for self-renewal, proliferation and multi-differentiation, which brings us the hope for regenerative medicine—renewing new organ or tissue cells to replace those damaged by injury or diseases. Although the mechanism of “plasticity” and its application in the regenerative medicine are still in doubt, thorough exploration in these subjects would open up broad prospects for the use in cell and tissue engineering in the near future. 相似文献
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Oct4 is mainly expressed in embryonic stem cells(ESCs),germline stem cells,and embryonal carcinoma cells(ECCs)and plays an indispensable role in maintaining the pluripotency and self-renewal of these pluripotent stem cells.Akt serine/threonine kinase,a wellestablished anti-apoptosis and cell survival factor,has also been implicated as an important regulator of stemness.Emerging evidence indicated that Oct4 is reciprocally connected to Akt via a number of routes,and moreover,a direct interaction between Oct4 and Akt has recently been revealed.These components collectively form the Akt–Oct4 regulatory circuit.In this review,we summarize our current knowledge about the Akt–Oct4 regulatory circuit in ESCs and discuss its alterations in ECCs that may underlie the tumorigenesis of pluripotent stem cells. 相似文献