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Zusammenfassung Trächtige Mäuse wurden zwei Tage vor dem erwarteten Werfen mit dem Antimetabolit des Methionins14C-DL-Aethionin intravenös behandelt. Aufnahme und Einbau des Antimetabolits wurden gleichzeitig autoradiographisch und chemisch untersucht. Die Plazentaschranke ist für Aethionin durchlässig; die Radioaktivität fand sich in den Foeten angehäuft, dabei war aber nur ein ganz geringer Teil des Aethionins in den Eiweisskörper derselben eingebaut. Der Einbau des Aethionins in den Organen (Leber und Pankreas) der Mutter war ebenfalls äusserst gering.Aus den Ergebnissen wird der Mechanismus der toxischen Wirkung des Aethionins erklärt.
This work was supported by grants from the Swedish Medical Research Council. 相似文献
This work was supported by grants from the Swedish Medical Research Council. 相似文献
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Summary The mutagenic potential of 1.0 Ci14C was evaluated in Swiss albino male mice by the dominant lethal assay. A significant increase in post-implantation loss was seen, the maximum being in the 3rd week after treatment.Authors express their thanks to University Grants Commission, New Delhi, for financial assistance. 相似文献
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Summary Buffalo spermatozoa exhibit insignificant uptake of glucose-C14 and fructose-C14 when semen samples were preserved in cold for 96 h in 2 extenders. Incorporation of C14 in spermatozoa, TCA precipitable proteins and soluble sugar phosphates was either equal or less in semen samples preserved in cold. CAW appeared to be a better extender than SKMEY as revealed by sugar uptake in cold.Acknowledgment. We are indebted to Dr D. Sundaresan, Director, for his kind encouragement in this study. 相似文献
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Buffalo spermatozoa exhibit insignificant uptake of glucose-C14 and fructose-C14 when semen samples were preserved in cold for 96 h in 2 extenders. Incorporation of C14 in spermatozoa, TCA precipitable proteins and soluble sugar phosphates was either equal or less in semen samples preserved in cold. CAW appeared to be a better extender than SKMEY as revealed by sugar uptake in cold. 相似文献
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Summary 3-H-tolbutamide was distributed in a volume exceeding the space occupied by 14-C-sucrose in islets as well as in liver, kidney, muscle, and fat. In contrast to previous reports, the findings suggest that tolbutamide is not restricted to the extracellular space of islets. 相似文献
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Summary The synthesis of molting hormone of cockroaches of which the prothoracic glands had previously been extirpated was investigated after injection of cholesterol-14C. It could be proved by means of radio thin-layer chromatography of extracts that ecdysterone and in small amounts ecdysone, are synthesized in Periplaneta americana larvae without prothoracic glands. The results demonstrate that other tissues are also able to perform the molting hormone besides the molting gland itself.Supported by the Sächsische Akademie der Wissenschaften zu Leipzig. 相似文献
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3-H-tolbutamide was distributed in a volume exceeding the space occupied by 14-C-sucrose in islets as well as in liver, kidney, muscle, and fat. In contrast to previous reports, the findings suggest that tolbutamide is not restricted to the extracellular space of islets. 相似文献
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H. S. Zackheim R. J. Feldmann C. Lindsay H. I. Maibach 《Cellular and molecular life sciences : CMLS》1977,33(6):753-754
Summary Following topical application of14C-labeled 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU, carmustine) to the skin of mice radioactivity was found in all viscera and tissues examined. Exclusive of the gut, highest values were recorded for the liver, kidney and lung.Supported by Public Health Service, grant CA 14825, from the National Cancer Institute, National Institutes of Health, Department of Health, Education and Welfare. 相似文献
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Résumé L'hémoglobine libre du sang, filtrée par les glomérules rénaux et partiellement absorbée par les tubules, est métabolisée par le tissu renal. A l'aide de l'hémoglobine marquée en14C, formée à partir de la glycine-2-14C et de la glycine-1-14C nos résultats prouvent que chez le chien mâle les reins métabolisent l'hémoglobine en bilirubine conjugée et excrètent cette dernière dans les urines.
Our thanks are due to the Fonds voor wetenschappelijk geneeskundig onderzoek of Belgium for the financial support. 相似文献
Our thanks are due to the Fonds voor wetenschappelijk geneeskundig onderzoek of Belgium for the financial support. 相似文献
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T. White 《Cellular and molecular life sciences : CMLS》1963,19(1):43-44
Zusammenfassung In narkotisierte Katzen wurde C14-Histamin entweder durch Hirnventrikel perfundiert oder intravenös injiziert. Seine Ausscheidung und Metabolite in Urin wurde gleichzeitig bestimmt: Ca. 2% des durch die Hirnventrikel perfundierten C14-Histamins wurde im Blutstrom resorbiert. 相似文献
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G. Andersson E. Hansson C. G. Schmiterlöw 《Cellular and molecular life sciences : CMLS》1965,21(4):211-213
Zusammenfassung Der Übertritt von C14-Nicotin aus der Magenschleimhaut von Mäusen, Ratten und Katzen in den Mageninhalt wurde autoradiographisch und mit Radioaktivitätsmessungen untersucht. Perfusionsversuche des Rattenmagens in situ ergaben eine pH-abhängige Nikotinausscheidung. Chromatographisch wurde die ausgeschiedene Radioaktivität teils im Nikotin selber, teils im Abbauprodukt Cotinin nachgewiesen.
This investigation was supported by grants from Svenska Tobaks AB and the American Medical Association. 相似文献
This investigation was supported by grants from Svenska Tobaks AB and the American Medical Association. 相似文献
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Summary [14C]Orotic acid was rapidly distributed in blood after, both i.p. and s.c. injection but was not completely absorbed from the peritoneal cavity until 20 min after injection. S.c. injection should be an acceptable alternative to i.p. injection although the incorporation into the liver acid soluble- and RNA-fractions was somewhat delayed after the s.c. injection.This work was supported by grants from the Carl Trygger Foundation and the Foundation of Director Albert Påhlsson. 相似文献
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