| 流动注射化学发光法测定药物中的雷尼替丁 |
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| 引用本文： | 吴芳辉,陈乐.流动注射化学发光法测定药物中的雷尼替丁[J].吉首大学学报(自然科学版),2012,33(6):82-84. |
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| 作者姓名： | 吴芳辉 陈乐 |
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| 作者单位： | (安徽工业大学化学与化工学院，安徽 马鞍山 243002) |
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| 基金项目： | 安徽省教育厅自然科学重点基金资助项目，安徽工业大学研究生创新研究基金 |
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| 摘 要： | 在硫酸介质中，硫酸铈氧化亚硫酸钠产生微弱的发光信号，而雷尼替丁可显著增强该体系的化学发光，由此建立了流动注射化学发光技术测定雷尼替丁的新体系.实验结果表明，该方法的检出限为9.8×10-7 mol/L，测定雷尼替丁的线性范围为3.0×10-6~2.5×10-4 mol/L.对5.0×10-5 mol/L雷尼替丁进行11次平行测定，其相对标准偏差为3.3%.将该方法用于药物胶囊中雷尼替丁的测定，结果令人满意.
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| 关 键 词： | 化学发光 硫酸铈 亚硫酸钠 雷尼替丁 |
Determination of Ranitidine in Drug Using Flow-Injection Chemiluminescence Method |
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| WU Fang-Hui,CHEN Le.Determination of Ranitidine in Drug Using Flow-Injection Chemiluminescence Method[J].Journal of Jishou University(Natural Science Edition),2012,33(6):82-84. |
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| Authors: | WU Fang-Hui CHEN Le |
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| Institution: | (School of Chemistry and Chemical Engineering,Anhui University of Technology,Ma’anshan 243002,Anhui China) |
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| Abstract: | A new chemiluminescence method for determination of ranitidine is proposed.The method is based on the enhancement of ranitidine on the chemiluminescence reaction among cerium sulphate and sodium sulfite in H2SO4 medium.The linear relationship between the intensity of chemiluminescence and the concentration of ranitidine is in the range of 3.0×10-6~2.5×10-4 mol/L with the detection limit of 9.8×10-7 mol/L.The relative standard deviation is 3.3% for 11 measurements of 5.0×10-5 mol/L ranitidine standard solution.This method has been successfully applied to determination of ranitidine in injections and drug capsules with satisfactory results. |
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| Keywords: | chemiluminescence cerium sulphate sodium sulfite ranitidine |
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