| 微波辅助下苯并噁唑衍生物的合成与结构表征 |
| |
| 引用本文： | 王帆,袁金伟,张瑞,买文鹏,杨亮茹,毛璞,屈凌波.微波辅助下苯并噁唑衍生物的合成与结构表征[J].河南师范大学学报(自然科学版),2015(1):69-73. |
| |
| 作者姓名： | 王帆 袁金伟 张瑞 买文鹏 杨亮茹 毛璞 屈凌波 |
| |
| 作者单位： | 河南工业大学化学化工学院 |
| |
| 基金项目： | 国家自然科学基金(21172055;21302042);河南省教育厅自然科学研究计划(2011B15007;12A15007;14B150053);郑州市科技创新团队(131PCXTD605) |
| |
| 摘 要： | 在微波辐射条件下,以邻氨基苯酚衍生物和原甲酸三乙酯为原料,发生分子间和分子内的消去反应合成了5种取代苯并噁唑化合物,其结构通过IR、NMR和ESI MS等证实.通过对反应影响因素的考察,最佳的反应条件是:在无溶剂条件下,邻氨基苯酚衍生物与原甲酸三乙酯的物质的量比为1∶1.5,反应温度为100℃,反应时间为15min,目标产物最高产率可达94.9%.
|
| 关 键 词： | 微波辅助 苯并噁唑 合成 结构表征 |
Microwave-assisted Synthesis and Structural Characteristic of Benzoxazole Derivatives |
| |
| WANG Fan;YUAN Jinwei;ZHANG Rui;MAI Wenpeng;YANG Liangru;MAO Pu;QU Lingbo.Microwave-assisted Synthesis and Structural Characteristic of Benzoxazole Derivatives[J].Journal of Henan Normal University(Natural Science),2015(1):69-73. |
| |
| Authors: | WANG Fan;YUAN Jinwei;ZHANG Rui;MAI Wenpeng;YANG Liangru;MAO Pu;QU Lingbo |
| |
| Institution: | WANG Fan;YUAN Jinwei;ZHANG Rui;MAI Wenpeng;YANG Liangru;MAO Pu;QU Lingbo;School of Chemistry and Chemical Engineering,Henan University of Technology; |
| |
| Abstract: | Under the condition of microwave radiation,a series of substituted benzoxazole derivatives were synthesized using the material of 2-aminophenol and triethyl orthoformate via the inter-and intramolecular elimination reaction.The structures of the title compounds were elucidated by IR、1 H NMR、13 C NMR and ESI MS.Furthermore,the reaction conditions were optimized as follows:reaction temperature 100 ℃,reaction time 15 min,the molar ratio of 2-aminophenol and triethyl orthoformate 1∶1.5,under solvent-free condition.Under the optimized conditions,the highest yield of target product reached94.9%. |
| |
| Keywords: | microwave-assisted benzoxazole synthesis structural characterization |
| 本文献已被 CNKI 等数据库收录！ |
|
