| 西洛多辛关键中间体合成工艺改进 |
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| 引用本文： | 张涛,范江,郎方,吴勇.西洛多辛关键中间体合成工艺改进[J].四川大学学报(自然科学版),2007,44(3):638-640. |
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| 作者姓名： | 张涛 范江 郎方 吴勇 |
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| 作者单位： | 四川大学华西药学院,成都,610041 |
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| 摘 要： | 1-乙酰吲哚啉与2-溴丙酰氯经付克酰化得到1-乙酰-5-(2-溴丙酰基)吲哚啉，再经三乙基硅烷还原、硝化，随后用氯化亚锡还原得到西洛多辛关键中间体1-乙酰-7-氨基-5-(2-溴丙基)吲哚啉，总收率70％.
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| 关 键 词： | 1-乙酰-7-氨基-5-(2-溴丙基)吲哚啉 西洛多辛 中间体 合成 |
| 文章编号： | 0490-6756（2007）03-0638-03 |
| 收稿时间： | 8/8/2006 12:00:00 AM |
| 修稿时间： | 2006-08-08 |
Improved synthesis of the key intermediate of silodosin |
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| ZHANG Tao,FAN Jiang,LANG Fang and WU Yong.Improved synthesis of the key intermediate of silodosin[J].Journal of Sichuan University (Natural Science Edition),2007,44(3):638-640. |
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| Authors: | ZHANG Tao FAN Jiang LANG Fang and WU Yong |
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| Institution: | West China School of Pharmacy,Sichuan University,West China School of Pharmacy,Sichuan University,West China School of Pharmacy,Sichuan University,West China School of Pharmacy,Sichuan University |
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| Abstract: | 1-acetyl-7-amino-5-(2-bromopropyl)indoline,a key intermediate of Silodosin,was synthesized from 1-acetyl indoline via Friedel Crafts acylation with 2-bromopropinoyl chloride,reduction with triethylsilane,nitration followed by reduction with tin dichloridein 70% overall yield. |
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| Keywords: | 1-acetyl-7-amino-5-(2-aminopropyl) indoline silodosin intermediate synthesis |
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