| 3,4-取代[1,2,4]三唑衍生物的合成及其表征 |
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| 引用本文： | 易绣光,张敏,严云逸,徐瑶,李雅静,赖飞平.3,4-取代[1,2,4]三唑衍生物的合成及其表征[J].井冈山大学学报（自然科学版）,2020,41(6):18-21. |
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| 作者姓名： | 易绣光 张敏 严云逸 徐瑶 李雅静 赖飞平 |
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| 作者单位： | 井冈山大学化学化工学院,江西,吉安 343009;国家电投集团新能源科技有限公司,江西,南昌,330096 |
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| 基金项目： | 江西省教育厅科技计划项目(GJJ190550);江西省自然科学基金项目(20202BAB204003);井冈山大学博士科研启动项目(JZB1905);井冈山大学国家级大学生创新创业计划项目 |
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| 摘 要： | 分别以3-氨基苯甲酸甲酯和3-溴基苯甲酸甲酯为起始原料,经过水合肼的肼解、DMF-DMA(N,N-二甲基甲酰胺二甲基缩醛)的氨基保护、关环等制备了一系列新的3,4-取代的1,2,4]三唑衍生物,并通过1H NMR对其进行结构表征及HPLC对目标化合物进行纯度分析。上述路线反应条件温和、无须色谱柱分离、更适合工业化生产。
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| 关 键 词： | 制备 3-氨基苯甲酸甲酯 3-溴基苯甲酸甲酯 三唑衍生物 |
| 收稿时间： | 2020/6/18 0:00:00 |
| 修稿时间： | 2020/9/17 0:00:00 |
PREPARATION, CHARACTERIZATION OF 3, 4-SUBSITUTED[1, 2, 4] TRIAZOLE DERIVATIVES |
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| YI Xiu-guang,ZHANG Min,YAN Yun-yi,XU Yao,LI Ya-jing and LAIi Fei-ping.PREPARATION, CHARACTERIZATION OF 3, 4-SUBSITUTED[1, 2, 4] TRIAZOLE DERIVATIVES[J].Journal of Jinggangshan University(Natural Sciences Edition),2020,41(6):18-21. |
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| Authors: | YI Xiu-guang ZHANG Min YAN Yun-yi XU Yao LI Ya-jing and LAIi Fei-ping |
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| Institution: | School of Chemistry and Chemical Engineering, Jinggangshan University, Ji''an, Jiangxi 343009, China,State Power Investment Group New Energy Technology Co., Ltd, Nanchang, Jiangxi 330096, China,School of Chemistry and Chemical Engineering, Jinggangshan University, Ji''an, Jiangxi 343009, China,School of Chemistry and Chemical Engineering, Jinggangshan University, Ji''an, Jiangxi 343009, China,School of Chemistry and Chemical Engineering, Jinggangshan University, Ji''an, Jiangxi 343009, China and School of Chemistry and Chemical Engineering, Jinggangshan University, Ji''an, Jiangxi 343009, China |
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| Abstract: | A series of new 3, 4-substituted1, 2, 4]-triazole derivatives were prepared from 3-aminobenzoic acid methyl ester and 3-bromobenzoic acid methyl ester by hydrazinolysis of hydrazine hydrate, amino protection of DMF-DMA, ring closing, respectively. The structure of the derivatives was characterized by 1H NMR and the purity of the target compounds was analyzed by HPLC. The reaction conditions of the above route are mild, without chromatographic column separation and more suitable for industrial production. |
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| Keywords: | synthesis 3-aminobenzoic acid methyl ester 3-bromobenzoic acid methyl ester triazole derivatives |
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