两种植物提取物对家兔颈总动脉血压影响的比较研究

以家兔为研究对象,探讨两色金鸡菊和芳香新塔花两种提取物对家兔颈总动脉血压、心率的影响,并比较其异同。试验将两色金鸡菊和芳香新塔花提取物各设低、中、高3个浓度组,采用生物信号系统采集、记录家兔颈总动脉血压,比较加药后各组家兔舒张压、收缩压和心率的变化。结果表明:两色金鸡菊和芳香新塔花提取物3个浓度组均能使家兔颈总动脉收缩压、舒张压明显下降,二种提取物对舒张压的影响比对收缩压的影响更明显,但对心率抑制影响并不明显。与芳香新塔花提取物相比,同剂量的两色金鸡菊提取物对家兔颈总动脉血压抑制更为明显。说明两色金鸡菊提取物比芳香新塔花提取物有更强的降血压作用。

COMPARATIVE STUDY ON THE EFFECTS OF TWO PLANT EXTRACTS ON THE BLOOD PRESSURE OF THE COMMON CAROTID ARTERY IN RABBITS

Taking rabbits as the research object,the effects of two kinds of extracts of Coreopsis tinctoria Nutt.and Ziziphora clinopodioides Lam.on the blood pressure and heart rate of common carotid artery in rabbits were studied,and their similarities and differences were compared.The extracts of C.tinctoria and Z.clinopodioides were divided into three concentration groups:low,medium and high concentrations.The diastolic blood pressure,systolic blood pressure and heart rate of rabbits were monitored by biological signal acquisition and processing system.The changes of diastolic blood pressure,systolic blood pressure and heart rate of rabbits in each group were compared after drug addition.The results showed that the effects of the two extracts on the diastolic blood pressure were more obvious than that on the systolic blood pressure,but the inhibition of heart rate was not obvious.Compared with the extract of Z.clinopodioides,the same dose of extract of C.tinctoria inhibited the blood pressure of rabbit carotid artery more significantly.The results suggested that the extract of C.tinctoria had stronger antihypertensive effect than that of Z.clinopodioides.