直接碘化反应高效合成碘代芳烃

以3-叔丁基水杨醛为原料,通过3种不同的碘化方法分别合成了3-叔丁基-5-碘水杨醛,在温和条件下,以水-乙醇为溶剂、KI为碘化试剂、H_2O_2为氧化剂有效合成了3-叔丁基-5-碘水杨醛.结果表明:在水/乙醇体积比为3∶1,H_2SO_4的质量浓度为62.5 mg·m L~(-1),反应物/KI/氧化剂摩尔比为1∶1∶2,反应温度为70℃,反应时间为6 h时,碘取代反应条件最佳.此时,3-叔丁基-5碘水杨醛摩尔收率高达88.1%,2,6-二氟苯胺和2,6-二异丙基苯胺在该条件下成功进行了碘化反应,产物摩尔收率分别可达87.3%和85.6%.

Efficient Synthesis of Iodine-substituted Aromatics by Direct Iodination

Metal based monolithic catalysts with different Cu-Ce ratios were prepared by using CuO-CeO₂ as active component and FeCrAl as support. The activity and stability of the catalysts were tested on a fixed bed reactor, and the structure of the catalysts before and after testing were characterized by XRD, TEM, XPS and other characterization methods. The results indicated that deactivation of the catalysts were mainly due to the aggregation of CuO particles and the decrease of Cu²⁺ content on the surface after the reaction.