3,5-二取代-4-氨基-1,2,4-三唑类衍生物的合成及生物活性研究

通过 ３取代４氨基５巯基１，２，４三唑与卤代烃之间的亲核取代反应合成了 １２ 种含烷硫（芳硫）基的１，２，４三唑类衍生物，结构经１ Ｈ Ｎ Ｍ Ｒ 及元素分析而确证，并对所合成的化合物进行了初步的生物活性测试，结果表明部分化合物表现出一定的除草活性和杀菌活性

Syntheses and bioactivity of 3,5 disubstituted 4 amino 1,2,4 triazole derivatives

Twelve 1,2,4 triazole derivatives containing arylthio or benzylthio groups are synthesized by the nucleophilic substitution reaction between 3 substituted 4 amino 5 mercapto 1,2,4 triazoles and substituted chlorobenzene or substituted benzyl chloride. All compounds synthesized are identified by 1H NMR and elemental analyses. The initial bioactive tests indicate that some compounds display herbicidal and fungicidal activity to some extent.