灵芝浸液对小鼠免疫功能的调节作用

报道了灵芝对Ｂａｌｂ／ｃ小鼠产生抗绵羊红细胞（ＳＲＢＣ）抗体的能力及对迟发性变态反应（ＤＨＴ）等免疫功能的影响。实验小鼠分为高、中、低剂量组，经胃灌注不同剂量的灵芝浸液，每天灌注１次，连续灌１５ｄ，对照组自由摄水。用ＳＲＢＣ免疫小鼠，免疫后第５ｄ用溶血空斑实验（ＰＦＣ）进行抗体生成细胞检测，以反映Ｂ细胞生成ＩｇＭ抗体的能力；于免疫后第４ｄ用足底增厚法测定ＤＨＴ强度，以检测Ｔ细胞功能；用碳粒廓清实验检测巨噬细胞吞噬功能。结果：高、中剂量组溶血空斑数目明显高于对照组，ｐ＜０．０５；高、中剂量组能明显提高小鼠ＤＨＴ反应程度，ｐ＜０．０５。表明灵芝能提高小鼠Ｔ细胞和Ｂ细胞的功能。碳粒廓清实验用药组与对照组无显著差异。

Immunomodulation of Ganoderma lucidumon DHT and Antibody Production of Mice

Immunomodulation effect of Ganoderma lucidum on antibody production cell(PFC) and delayed hypersensitivity(DHT) of mice were studied. Extract of Ganoderma lucidum divided into three dosages which were high and middle and low was infused into stomach of Balb/c mice for 15 days and in the control group,freely intaking water. The spleen cell PFC test and DHT test were measured in 4 groups after immunization by SRBC. The carbon granules Clearance Test was measure too. The extract was proved to be significantly increasing PFC p< 0.05 (include high and middle dosage) and DHT p<0.05 for experimental groups (in high dosage).But Clearance Test had no change . Thus Ganoderma lucidum might be regarded as an immune enhancer. It can enhance the abilities of T and B lymphocytes.