| 1-(2-(4-取代)苯氧乙基)-1H-1,2,3-三氮唑衍生物的合成及其抗菌活性研究 |
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| 引用本文： | 刘进兵,张春霞,李秀玲,林崇懒,宋化灿.1-(2-(4-取代)苯氧乙基)-1H-1,2,3-三氮唑衍生物的合成及其抗菌活性研究[J].中山大学学报(自然科学版),2008,47(2):65-68. |
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| 作者姓名： | 刘进兵 张春霞 李秀玲 林崇懒 宋化灿 |
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| 作者单位： | 1. 中山大学化学与化学工程学院,广东,广州,510275
2. 郑州轻工业学院材料与化学工程学院,河南,郑州,450002 |
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| 摘 要： | 设计并合成了8个未曾见文献报道的1-(2-(4-取代)苯氧乙基)-1H-1,2,3-三氮唑衍生物，并通过NMR、IR、MS确认了化合物的结构。以克拉霉素和左氧氟沙星为参照物，对8个化合物进行了金黄色葡萄球菌、大肠杆菌和绿脓杆菌的体外抑制活性测试，测试结果表明其中一种化合物对金黄色葡萄球菌表现出一定的抗菌活性(MIC50＝64 μg/mL)。
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| 关 键 词： | 3 -三氮唑 合成 抗菌活性 |
| 文章编号： | 0529-6579(2008)02-0065-04 |
| 收稿时间： | 2007-09-18; |
| 修稿时间： | 2007年9月18日 |
Synthesis of 1-(2-(4-Subsitituted) Phenyloxyethyl)-1,2,3-Triazole Derivatives and their Antibacterial Activity |
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| LIU Jin-bing,ZHANG Chun-xia,LI Xiu-ling,LIN Chon-lan,SONG Hua-can.Synthesis of 1-(2-(4-Subsitituted) Phenyloxyethyl)-1,2,3-Triazole Derivatives and their Antibacterial Activity[J].Acta Scientiarum Naturalium Universitatis Sunyatseni,2008,47(2):65-68. |
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| Authors: | LIU Jin-bing ZHANG Chun-xia LI Xiu-ling LIN Chon-lan SONG Hua-can |
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| Institution: | (1.School of Chemistry and Chemical Engineering,Sun Yat sen University,Guangzhou 510275,China);2.Department of chemical engineering,Zhengzhou University of Light Industry,Zhengzhou 450002,China) |
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| Abstract: | Eight new compounds of 1-(2-(4-subsitituted)phenyloxyethyl)-1,2,3-triazole derivatives were synthesized.Their structures were characterized by NMR,IR,and MS analyses.Their antibacterial activities against Gram negative bacteria in vitro,including Staphylococcus aureus (ATTC-25923),Escherichia coli(ATTC-25922),Pseudomonas aeruginosa (ATTC-27853)were investigated.The results indicated that one compound of them showed modest activity against Staphylococcus aureus. |
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| Keywords: | 3-triazole synthesis antibacterial activity antigens |
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