莫扎特K.448对颞叶癫痫模型鼠高频脑电活性的影响

选用C57BL/6小鼠,随机分为两组.实验组小鼠通过匹罗卡品(PILO)腹腔注射,诱发癫痫持续状态(SE);对照组给予等容量生理盐水.SE后4周测试小鼠听力,SE后6~7周播放莫扎特K.448,探究莫扎特K.448对颞叶癫痫模型鼠自发发作期高频脑电(EEG)活性的影响.数据显示,PILO注射未明显影响小鼠的听力,给予莫扎特K.448使对照组与SE模型鼠在55~145 Hz区间的功率谱显著升高.结果表明,短时期给予莫扎特K.448音乐治疗能导致小鼠EEG高频活性增强.

Effects of Mozart K. 448 on High-Frequency EEG Activities in Temporal Lobe Epilepsy Model Mice

C57BL /6 mice were randomly divided into two groups. The mice in experimental group were given intraperitoneal injection of pilocarpine( PILO) to evoke status epilepticus( SE),and the mice in control group were given saline with the same volume. Auditory capacities of mice were tested at 4 weeks after the onset of SE,and to investigate effects of Mozart K. 448 on high frequency electroencephalogram( EEG) activities at spontaneous recurrent seizure state in temporal lobe epilepsy model mice. Mozart K. 448 was played at 6 to 7 weeks after the onset of SE. According to experimental data,PILO-injected not affect auditory capacities of mice significantly and Mozart K. 448 therapy enhanced EEG activity at frequencies between 55 Hz to 145 Hz both in control and SE model mice. The results showed that short-term playing of Mozart K. 448 enhanced high frequency EEG activities.