| 海马BDNF和iNOS与慢性应激性抑郁的关系 |
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| 引用本文： | 王丹.海马BDNF和iNOS与慢性应激性抑郁的关系[J].信阳师范学院学报(自然科学版),2010,23(2). |
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| 作者姓名： | 王丹 |
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| 作者单位： | 西安文理学院,生命科学系,陕西,西安,710065 |
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| 基金项目： | 西安文理学院专项科研基金项目 |
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| 摘 要： | 建立慢性不可预见性抑郁动物模型,采用液体消耗实验(fluid consumption test,FCT)、敞箱实验(Open field test,OFT)和强迫游泳(Forced swimming test,FST)等方法进行行为学测试,并用免疫组织化学的方法检测海马BDNF和iNOS的表达,运用腹腔注射药物的方法探索BDNF和iNOS的作用与关系.探讨了海马脑源性神经营养因子(BDNF)和诱导型一氧化氮合酶(iNOS)在慢性应激诱导的抑郁症中的关系,及抑郁症的发病机制.与对照组相比,慢性不可预见性应激(Chronic unpredicted mild stress,CUMS)组大鼠的行为学表现能力下降,BDNF表达下降(n=8,P0.01),iNOS的表达升高(n=8,P0.01);阻断内源性BDNF大鼠的行为学表现能力也下降,iNOS的表达升高(n=7,P0.01);而海马微量注射iNOS的抑制剂SMT均可反转CUMS和BDNF抑制剂所导致的行为学表现能力下降的现象.慢性不可预见性应激引起海马BDNF表达下降,NO过高而导致抑郁.BDNF对神经元具有保护作用,BDNF的抗抑郁作用可能是通过抑制iNOS的表达而起作用的.提示BDNF等神经保护因子通过抑制iNOS的过量表达而保护脑组织可能是治疗抑郁症的一个重要途径.
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| 关 键 词： | 脑源性神经营养因子 诱导型一氧化氮合酶 慢性不可预见性应激 海马 抑郁 |
Sequental Involvement of Hippocampal BDNF and Inducible Nitric Oxide in Depression Induced by Chronic Unpredicted Mild Stress |
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| WANG Dan.Sequental Involvement of Hippocampal BDNF and Inducible Nitric Oxide in Depression Induced by Chronic Unpredicted Mild Stress[J].Journal of Xinyang Teachers College(Natural Science Edition),2010,23(2). |
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| Authors: | WANG Dan |
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| Institution: | WANG Dan*(Department of Life Sciences,Xi\'an University of Arts , Science,Xi\'an 710065,China) |
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| Abstract: | The rat model of depression was established by exposing to an unpredictable sequence of stressors.By means of fluid consumption test,forced swimming test and open file test,the behaviors of the animals were determined,and the expression of brain derived neurotrophic factor(BDNF) and neuron Nitric-oxide Synthase(iNOS).And in rat hippocampal were observed.The effects of chronic and unpredictable stress on the pathological changes and expression of iNOS and BDNF of rat hippocampal and behavioral changes were o... |
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| Keywords: | BDNF inos CUMS hippocampal depression |
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