| 三种苦参碱衍生物的合成与表征 |
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| 引用本文： | 王立升,冉炜,刘帅兵,梁鹏云,刘布鸣,刘旭,林霄,陈明生.三种苦参碱衍生物的合成与表征[J].广西大学学报(自然科学版),2012,37(3):495-497. |
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| 作者姓名： | 王立升 冉炜 刘帅兵 梁鹏云 刘布鸣 刘旭 林霄 陈明生 |
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| 作者单位： | 1. 广西大学化学化工学院,广西南宁,530004
2. 广西中药质量标准研究重点实验室,广西南宁,530022 |
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| 基金项目： | 广西自然科学基金重点项目，广西中药质量标准研究重点实验室开放基金 |
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| 摘 要： | 为了发现基于苦参碱的具备良好抗炎活性的化合物,以苦参碱为原料,在二异丙基氨基锂的催化作用下经亲核取代反应合成得到3个未见文献报道的苦参碱衍生物。经实验证实,在反应温度-5℃,反应时间2 h的条件下产率最高。利用红外光谱(IR)、核磁共振氢谱(1H-NMR)、质谱(MS)对所合成的化合物进行了结构表征。
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| 关 键 词： | 苦参碱 衍生物 合成 |
Synthesis and characterization of three matrine derivatives |
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| WANG Li-sheng
,
RAN Wei
,
LIU Shuai-bing
,
LIANG Peng-yun
,
LIU Bu-ming
,
LIU Xu
,
LIN Xiao
,
CHEN Ming-sheng.Synthesis and characterization of three matrine derivatives[J].Journal of Guangxi University(Natural Science Edition),2012,37(3):495-497. |
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| Authors: | WANG Li-sheng RAN Wei LIU Shuai-bing LIANG Peng-yun LIU Bu-ming LIU Xu LIN Xiao CHEN Ming-sheng |
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| Institution: | 1.School of Chemistry and Chemical Engineering,Guangxi University,Nanning 530004,China; 2.Guangxi Key Laboratory of Traditional Chinese Medicine Quality Standards,Nanning 530022,China) |
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| Abstract: | To find compounds with good anti-inflammatory activity,three new derivatives of matrine were synthesized via nucleophilic substitution under the catalysis of lithium diisopropylamide.It was confirmed by experiments that the yield was highest under the condition of the reaction temperature at-5 ℃ and the reaction time of 2 h.The structures of these derivatives were characterized by infrared spectroscopy(IR),nuclear magnetic resonance(NMR) and mass sprctrometry(MS). |
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| Keywords: | matrine derivative synthesis |
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