| 醋酸去氢表雄酮肟的合成及其抗菌活性研究 |
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| 引用本文： | 田光辉.醋酸去氢表雄酮肟的合成及其抗菌活性研究[J].陕西理工学院学报(自然科学版),2012(1):63-67. |
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| 作者姓名： | 田光辉 |
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| 作者单位： | 陕西理工学院化学与环境科学学院 |
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| 基金项目： | 陕西省科技厅社会发展计划项目(2009K11-03-3);陕西省科技厅“13115”科技创新工程项目(2010ZDGC-23-13) |
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| 摘 要： | 以醋酸去氢表雄酮为原料,室温搅拌下和盐酸羟胺在弱碱性介质中反应合成醋酸去氢表雄酮肟,得到了纯度较高的醋酸去氢表雄酮肟,收率达89.6%。通过测定其熔点,借助紫外光谱(UV)、红外光谱(IR)、核磁共振谱(NMR)、质谱(MS)以及元素分析等技术来表征其结构。抗菌活性实验表明,醋酸去氢表雄酮肟对实验菌株均有抑制和灭活作用,对枯草芽胞杆菌CMCC63501株的作用表现得更为明显。
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| 关 键 词： | 醋酸去氢表雄酮 酮肟 合成 结构表征 抗菌活性 |
Synthesis and antimicrobial activities of dehydroepiandrosterone oxime acetate |
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| TIAN Guang-hui.Synthesis and antimicrobial activities of dehydroepiandrosterone oxime acetate[J].Journal of Shananxi University of Technology:Natural Science Edition,2012(1):63-67. |
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| Authors: | TIAN Guang-hui |
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| Institution: | TIAN Guang-hui (School of Chemistry and Environment Science,Shaanxi University of Technology,Hanzhong 723001,China) |
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| Abstract: | The target compound 3-β-hydroxy-deoxyandrost-5-ene-17-one oxime-3-acetate was synthesized in alkalescence medium with 3-β-hydroxy-deoxyandrost-5-ene-17-one-3-acetate and hydroxylamine hydrochloride at room temperature by churn-dasher,purer dehydroepiandrosterone oxime acetate was obtained and its yield reached 89.6%.The melting point of this target compound was determined and its structure was fully characterized by UV,IR,NMR,MS and elemental analysis.The antimicrobial activities of dehydroepiandrosterone oxime acetate was evaluated by inhibiting the growth of four bacteria.The results showed that the target compound inhibited the growth of testing bacteria and sterilized them,and showed higher antimicrobial activity especially against bacillus subtillis CMCC63501. |
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| Keywords: | dehydroepiandrosterone acetate oxime synthesis characterization antimicrobial activity |
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