| 壳聚糖-5-氟尿嘧啶高分子前药的合成与表征 |
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| 引用本文： | 李和平,阮建明,蔡红革,潘彤.壳聚糖-5-氟尿嘧啶高分子前药的合成与表征[J].长沙理工大学学报(自然科学版),2005,2(4):84-88. |
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| 作者姓名： | 李和平 阮建明 蔡红革 潘彤 |
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| 作者单位： | 长沙理工大学,化学与环境工程系,湖南,长沙,410076;中南大学,粉末冶金国家重点实验室,湖南,长沙,410083;中南大学,粉末冶金国家重点实验室,湖南,长沙,410083;长沙理工大学,化学与环境工程系,湖南,长沙,410076 |
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| 基金项目： | 国家科技攻关项目;湖南省教育厅科研项目 |
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| 摘 要： | 为了合成控释型高分子前药，以壳聚糖为载体材料、5-氟尿嘧啶为模型药物，设计并合成了壳聚糖-5-氟尿嘧啶高分子前药，其结构经红外光谱、紫外-可见光谱证明．采用紫外一可见光谱仪，测得其载药率为16．4％．在pH为7．2的磷酸盐缓冲溶液中，1个月的累积释药量约占总含药量的68％，表现出明显的缓释效果．
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| 关 键 词： | 壳聚糖 5-氟尿嘧啶 高分子前药 合成 表征 |
| 文章编号： | 1672-9331（2005）04-0084-06 |
| 收稿时间： | 2005-01-27 |
| 修稿时间： | 2005年1月27日 |
Synthesis and Characterization of Chitosan-5-Fluorouracil Macromolecule Prodrug |
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| LI He-ping,RUAN Jian-ming,CAI Hong-ge,PAN Tong.Synthesis and Characterization of Chitosan-5-Fluorouracil Macromolecule Prodrug[J].Journal of Changsha University of Science and Technology:Natural Science,2005,2(4):84-88. |
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| Authors: | LI He-ping RUAN Jian-ming CAI Hong-ge PAN Tong |
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| Institution: | 1. Department of Chemistry and Environmental Engineering, Changsha University of Science and Technology, Changsha 410076, China; 2. State Key Laboratory for Powder Metallurgy, Central South University, Changsha 410083, China |
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| Abstract: | In order to synthesize control-releasing macromolecule prodrug,5-Fu-chitosan was synthesized by chitosan and 5-fluorouracil(5-Fu).As a model drug,5-Fu was conjugated into chitosan via chemical bond.The structure has been characterized by IR and UV-vis spectrum.The loaded capacity and drug releasing properties were investigated through UV-vis spectrum.The results indicated that the loaded capacity of Chitosan(CS)-5-fluorouracil(5-Fu) pre-drugs was 16.4%,and cumulative release percentage in the phosphate buffer(pH = 7.2) solutions was 68% in 30 days,the drug releasing rate was found decreased and it could make initial burst reduced. |
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| Keywords: | chitosan 5-fluorouracil macromolecule prodrug synthesis characterization |
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