| 7-羟基黄酮和7,8-二羟基黄酮的改良合成与结构修饰 |
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| 引用本文： | 汪秋安,廖头根,汤建国,范华芳.7-羟基黄酮和7,8-二羟基黄酮的改良合成与结构修饰[J].湖南大学学报(自然科学版),2004,31(5):1-4. |
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| 作者姓名： | 汪秋安 廖头根 汤建国 范华芳 |
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| 作者单位： | 湖南大学,化学生物传感与计量学国家重点实验室,化学化工学院,湖南,长沙,410082 |
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| 基金项目： | 化学生物传感与计量学国家重点实验室开放基金资助(2003) |
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| 摘 要： | 利用改良的Baker-Venkatarama重排法，以乙酰芳基酚为原料，经过二步反应合成了7-羟基黄酮(3a)和7，8-二羟基黄酮(3b)．通过对7-羟基黄酮和7，8-二羟基黄酮A环酚羟基的结构修饰，分别合成了三个7位取代和二个含苯并二氧杂环的新黄酮衍生物(4-6，7a，7b)．所合成化合物的结构已由MS，^1HNMR，IR等波谱方法所证实、
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| 关 键 词： | 7-羟基黄酮 7，8-二羟基黄酮 合成 结构修饰 |
| 文章编号： | 1000-2472(2004)05-0001-04 |
| 修稿时间： | 2004年6月28日 |
Improved Synthesis and Structure Modification of 7-Hydroxylflavone and 7,8-Dihydroxylflavone |
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| WANG Qiu-an,LIAO Tou-gen,TANG Jian-guo,FAN Hua-fang College of Chemistry and Chemical Engineering,Hunan Univ,Changsh,China.Improved Synthesis and Structure Modification of 7-Hydroxylflavone and 7,8-Dihydroxylflavone[J].Journal of Hunan University(Naturnal Science),2004,31(5):1-4. |
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| Authors: | WANG Qiu-an LIAO Tou-gen TANG Jian-guo FAN Hua-fang College of Chemistry and Chemical Engineering Hunan Univ Changsh China |
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| Institution: | WANG Qiu-an,LIAO Tou-gen,TANG Jian-guo,FAN Hua-fang College of Chemistry and Chemical Engineering,Hunan Univ,Changsha410082,China) |
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| Abstract: | 7-hydroxylflavone (3a) and 7,8-dihydroxyflavone (3b) were synthesized starting from acetyl aryl phenols in a two-step reaction in the improved Baker-Venkatarama rearragement synthetic method of flavones. Then, three new flavone derivatives (4-6) with 7-substituted flavones and two new flavone derivatives(7a, 7b) containing benzodioxane heterocyclas were synthesized by modifying the phenolic hydroxyl in A-ring of 7-hydroxylflavone and 7,8-dihydroxyflavone. All of these synthesized flavone compounds were proved in MS, 1HNMR and IR spectroscopic methods. |
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| Keywords: | 7-hydroxylflavone 7 8-dihydroxyflavone synthesis structure modification |
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