| 硫酸氢黄连素脂质体的制备工艺研究 |
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| 引用本文： | 万东华,高瑜,周训胜,许小平.硫酸氢黄连素脂质体的制备工艺研究[J].福州大学学报(自然科学版),2004,32(1):98-100. |
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| 作者姓名： | 万东华 高瑜 周训胜 许小平 |
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| 作者单位： | 福州大学化学化工学院,福建,福州,350002 |
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| 摘 要： | 以薄膜分散-超声法制备硫酸氢黄连素(Bb)脂质体.探讨了影响Bb脂质体包封率的因素,确定了最佳处方及实验条件,使包封率达57.5%,经电镜观察所制得的脂质体为微球状的大单室脂质体.
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| 关 键 词： | 硫酸氢黄连素 脂质体 包封率 制备 |
| 文章编号： | 1000-2243(2004)01-0098-03 |
| 修稿时间： | 2003年8月21日 |
Studies on the preparation technology of berberine bisulfate liposomes |
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| WAN Dong-hu,GAO Yu,ZHOU Xun-sheng,XU Xiao-ping.Studies on the preparation technology of berberine bisulfate liposomes[J].Journal of Fuzhou University(Natural Science Edition),2004,32(1):98-100. |
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| Authors: | WAN Dong-hu GAO Yu ZHOU Xun-sheng XU Xiao-ping |
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| Institution: | (College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou, Fujian 350002, China) |
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| Abstract: | The berberine(Bb) bisulfate liposomes were prepared by the thin-film hydration and ultrasonic technique. The effects of entrapment efficiency were investigated. The percentage of encapsulation is 57.5% under the optimized formulation and preparation techniques. With the help of electronic microscopy, we found that almost all the Bb liposomes were large unilamellar vesicles. |
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| Keywords: | berberine bisulfate liposomes entrapment efficiency preparation |
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