| 系列樟脑型β-二酮化合物的合成 |
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| 引用本文： | 谢运,骆开均,蒋世平,徐玲玲.系列樟脑型β-二酮化合物的合成[J].四川师范大学学报(自然科学版),2011,34(1):91-94. |
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| 作者姓名： | 谢运 骆开均 蒋世平 徐玲玲 |
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| 作者单位： | 四川师范大学化学与材料科学学院,四川,成都,610066 |
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| 基金项目： | 国家自然科学基金(21072141); 四川省教育厅自然科学重点基金(08ZA040)资助项目 |
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| 摘 要： | 樟脑由于具有较大的空间位阻,其α位的亚甲基较直链α位碳难活化.从D(+)-樟脑出发,采用高沸点的乙二醇二乙醚做溶剂,氢化钠作碱催化剂,合成了3-苯甲酰基樟脑,3-乙酰基樟脑和3-三氟乙酰基樟脑等系列樟脑型β-二羰基化合物,产率为30%～58.3%.目标产物用1H NMR,质谱(MS)来表征.并讨论了溶剂,碱催化剂以及提纯方法对反应的影响.
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| 关 键 词： | D(+)-樟脑 合成 樟脑型β-二酮 |
Synthesis of a Series of Camphor-type β-dione Compounds |
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| XIE Yun,LUO Kai-jun,JIANG Shi-ping,XU Ling-ling.Synthesis of a Series of Camphor-type β-dione Compounds[J].Journal of Sichuan Normal University(Natural Science),2011,34(1):91-94. |
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| Authors: | XIE Yun LUO Kai-jun JIANG Shi-ping XU Ling-ling |
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| Institution: | XIE Yun,LUO Kai-jun,JIANG Shi-ping,XU Ling-ling(College of Chemistry and Material Science,Sichuan Normal University,Chengdu 610086,Sichuan) |
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| Abstract: | The α-methylene of camphor is very hard to be activated because of the steric hindrance.In this paper,a series of camphor-type β-dione compounds are synthesized by using D(+)-camphor as starting material,ethylene glycol diethyl ether as solvent,and sodium hydride as a basic catalyst.The target compounds are obtained in a yield of 30%~58.3% and are characterized by 1H NMR and MS.The influences of solvent,basic catalyst and purification method on the reaction are also discussed. |
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| Keywords: | D(+)-camphor synthesis camphor-type β-dione |
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