肝组织工程支架的仿生设计与有限元分析

为了解决细胞在细胞支架复合培养中难以植入的问题,提出了一种卷裹型支架.将平面多孔支架采用卷裹的方式成型,使细胞在整个支架内部形成螺旋状三维分布,支架表面的管道结构可使培养液在支架内部渗透,从而提高物质交换效率.提出了一种具有仿生参数的流道设计方案,从肝脏血管铸型中提取血管的形状数据,作为仿生学依据进行流道设计,具体为树状多层分支结构.用此流道结构仿生了动脉、静脉的血液循环功能,并利用多孔材料仿生了毛细血管的渗透功能.建立了不同形状参数的流场分析模型,进行流体与多孔材料的渗流分析.结果表明,仿生设计方案的流场分布最为均匀,且平均流速较高,间接表明营养物质的输送效率最高.该支架能够使细胞呈三维分布,并扩大培养液在支架内的有效分布范围,更好地维持细胞的存活、增殖和迁移,为向组织化方向发展奠定了一定的基础.

Bionics Design and Finite-Element Analysis for Liver Tissue Engineering Scaffold

For three-dimensional cell spreading,a tube type scaffolds constructed by porous rolling plane is designed,and cells seeded on the surface are bent as a spiral.The channels in the scaffold promote culture medium permeating and material interchange.A bionic structure designed for this kind of scaffold is beneficial to measure the shape of liver vessels from liver vascular casting and extract the bionics parameters by statistic analysis,which has different hierarchies as a tree to imitate the functions of art...