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| Disc-Electrospun PCL Nanofiber Formed Micro-patterned Structure Scaffold | |
| 作者姓名： | 潘信 李大伟 曾志文 孙彬彬 柯勤飞 莫秀梅 |
| 作者单位： | [1]College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, China; [2]Engineering Research Center of Technical Textiles, Donghua University, Shanghai 201620, China; [3]College of Life and Environmental Sciences, Shanghai Normal University, Shanghai, 200234, China |
| 基金项目： | National Natural Science Foundations of China(Nos.30973105,31271035);Science and Technology Comission of Shanghai Municipality,China(No.11nm0506200);Ph.D.Programs Foundation of Ministry of Education of China(No.20130075110005) |
| 摘 要： | Disc-electrospinning using a disc as spinneret and a rotary drum as collector is a novel technology to prepare nanofiber which has been applied in tissue engineering scaffolds. In this study, nanofibrous mats with mlcro-patterned structure were fabricated via disc-electrospinning. Poly （ε-eaprolactone） （PCL） was dissolved in trifluoroethanol （TFE） at various concentrations （ 2 %-7 % ） （w/v） for electrospinning and the applied voltage ranged from 40 to 70 kV. Scanning electron microscopy （SEM） was employed to observe the morphology of the nanofibrous scaffolds. SEM images illustrated that the nanofibers with beads formed micro-patterned structure such as triangles and other polygons. The average diameter of nanofibers presented various size with the concentration increased from 2% to 7%. The beads on the nanofibers constructed the vertexes of the polygons, while nanofibers bridged between adjacent vertexes. The concentration of solution and applied voltage may be two dominant factors to influence the topological structure of the nanofibrons scaffolds. Cells cultured on the micro-patterned scaffold spread along the edges of the polygons. The scaffold with patterned structure may have a promising application in tissue engineering. |
| 关 键 词： | disc-electrospun poly ( S-caprolactone ) (PCL) patternedstructure beaded-fibers scaffold |
Disc-Electrospun PCL Nanofiber Formed Micro-patterned Structure Scaffold |
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| PAN Xin,LI Da-wei,ZENG Zhi-wen,SUN Bin-bin,KE Qin-fei,MO Xiu-mei.Disc-Electrospun PCL Nanofiber Formed Micro-patterned Structure Scaffold[J].Journal of Donghua University,2014,31(5):595-598. | |
| Authors: | PAN Xin LI Da-wei ZENG Zhi-wen SUN Bin-bin KE Qin-fei MO Xiu-mei |
| Institution: | 1. College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, China 2. College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, China;Engineering Research Center of Technical Textiles, Donghua University, Shanghai 201620, China 3. Engineering Research Center of Technical Textiles, Donghua University, Shanghai 201620, China;College of Life and Environmental Sciences, Shanghai Normal University, Shanghai, 200234, China |
| Abstract: | Disc-electrospinning using a disc as spinneret and a rotary drum as collector is a novel technology to prepare nanofiber which has been applied in tissue engineering scaffolds.In this study,nanofibrous mats with micro-patterned structure were fabricated via disc-electrospinning.Poly( #-caprolactone)( PCL) was dissolved in trifluoroethanol( TFE) at various concentrations( 2%-7%)( w / v)for electrospinning and the applied voltage ranged from 40 to 70 kV.Scanning electron microscopy( SEM) was employed to observe the morphology of the nanofibrous scaffolds.SEM images illustrated that the nanofibers with beads formed micro-patterned structure such as triangles and other polygons.The average diameter of nanofibers presented various size with the concentration increased from 2% to 7%.The beads on the nanofibers constructed the vertexes of the polygons,while nanofibers bridged between adjacent vertexes.The concentration of solution and applied voltage may be two dominant factors to influence the topological structure of the nanofibrous scaffolds.Cells cultured on the micro-patterned scaffold spread along the edges of the polygons.The scaffold with patterned structure may have a promising application in tissue engineering. |
| Keywords: | disc-electrospun poly (ε-caprolactone) (PCL) patterned structure beaded-fibers scaffold |
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