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| 谷胱甘肽过氧化物酶模拟物6-CySeCD对过氧化氢诱导小鼠成纤维细胞损伤的保护作用 | |
| 引用本文： | 徐亚维,闫岗林,龚平生,牟颖,罗贵民,杨佳,吕绍武.谷胱甘肽过氧化物酶模拟物6-CySeCD对过氧化氢诱导小鼠成纤维细胞损伤的保护作用[J].吉林大学学报(理学版),2010,48(2). |
| 作者姓名： | 徐亚维 闫岗林 龚平生 牟颖 罗贵民 杨佳 吕绍武 |
| 作者单位： | 1. 吉林大学,分子酶学工程教育部重点实验室,长春,130021;吉林农业科技学院,生物工程系,吉林,吉林,132001 2. 吉林大学,分子酶学工程教育部重点实验室,长春,130021 3. 长春西诺生物科技有限公司,长春,130021 |
| 基金项目： | 国家自然科学基金(批准号:20572035;30970608);;吉林大学基本科研业务费项目(批准号:200903093) |
| 摘 要： | 考察不同剂量的H2O2作用于小鼠成纤维细胞(NIH3T3)后,细胞脂质过氧化、存活率、DNA片段化的变化情况,并研究谷胱甘肽过氧化物酶(GPX)的模拟物6A,6B-环己胺-6A′,6B′-硒桥联-β-CD(6-CySeCD)抗H2O2诱导小鼠成纤维细胞损伤的能力.结果表明:H2O2对NIH3T3细胞有严重损伤;6-CySeCD能有效保护细胞,防止紫外线引起的损伤. |
| 关 键 词： | 谷胱甘肽过氧化物酶（GPX） 模拟物 6-CySeCD 过氧化氢 成纤维细胞 |
GPX Mimic 6-CySeCD Protecting Mouse Fibroblast Cell NIH3T3 from Damage Induced by H_2O_2 |
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| XU Ya-wei,YAN Gang-lin,GONG Ping-sheng,MU Ying,LUO Gui-min,YANG Jia,L Shao-wu.GPX Mimic 6-CySeCD Protecting Mouse Fibroblast Cell NIH3T3 from Damage Induced by H_2O_2[J].Journal of Jilin University: Sci Ed,2010,48(2). | |
| Authors: | XU Ya-wei YAN Gang-lin GONG Ping-sheng MU Ying LUO Gui-min YANG Jia L Shao-wu |
| Institution: | 1. Key Laboratory for Molecular Enzymology and Enginnering of Ministry of Education;Jilin University;Changchun 130021;China;2. Department of Bioengineering;Jilin Agricultural Science and Technology College;Jilin 132001;Jilin Province;3. Fassino Bio-Technology Co. Ltd;China |
| Abstract: | The antioxidant effect of 6A,6A′-cyclohexylamine-6B,6B′-selenium-bridged-β-cyclodextrin (6-CySeCD),a new mimic of glutathione peroxidase (GPX),was confirmed with a model system in which mouse fibroblast cell NIH3T3 were damaged by H_2O_2. The cell damage was characterized in terms of the lipid peroxidation of the cells,cell viability,DNA lysis rate. The injury effects of H_2O_2 and protection effects of 6-CySeCD on the cells were studied via the model system. The results show the 6-CySeCD could be able to protect cells from the damage induced by H_2O_2. |
| Keywords: | 6-CySeCD glutathione peroxidase (GPX) mimic 6-CySeCD hydrogen peroxide fibroblast cell |
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