| 皮芯结构的纤维基组织工程肌腱支架的制备及性能研究 |
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| 引用本文： | 郭正,张佩华.皮芯结构的纤维基组织工程肌腱支架的制备及性能研究[J].河南大学学报(自然科学版),2012,42(4):412-415. |
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| 作者姓名： | 郭正 张佩华 |
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| 作者单位： | 1. 中原工学院纺织学院,郑州450007;中原工学院河南省功能性纺织材料重点实验室,郑州450007
2. 东华大学纺织学院,上海201620;东华大学产业用纺织品教育部工程研究中心,上海201620 |
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| 基金项目： | 河南省基础与前沿技术研究计划项目资助(112300413225) |
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| 摘 要： | 以聚乙交酯(polyglycolide,PGA)纤维和聚丙交酯(polylactide,PLA)纤维为原料,采用小口径针织技术制备了一种具有皮芯结构的新型纤维基组织工程肌腱支架.对支架的体外降解行为及细胞在支架上的黏附情况进行了研究.研究表明,支架的整个降解过程分为“强力下降期”、“质量损失期”、“准稳定期”三个阶段,细胞在支架的皮层和芯层上均黏附较好,而且分泌了大量的细胞外基质.
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| 关 键 词： | 聚乙交酯 聚丙交酯 纤维 支架 降解 |
Preparation and Property of a Fiber Based Scaffold with a Skin-Core Structure for Tendon Tissue Engineering |
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| GUO Zheng
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ZHANG Pei-hua.Preparation and Property of a Fiber Based Scaffold with a Skin-Core Structure for Tendon Tissue Engineering[J].Journal of Henan University(Natural Science),2012,42(4):412-415. |
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| Authors: | GUO Zheng ZHANG Pei-hua |
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| Institution: | 1.Zhongyuan University of Technology a.College of Textile b.Henan Key Laboratory of Functional Textiles Material,Zhengzhou 450007,China;2.Donghua University a.College of Textile b.Engineering Research Center of Technical Textiles,Ministry of Education,Shanghai 201620,China) |
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| Abstract: | A fiber based scaffold with a skin-core structure for tendon tissue engineering was prepared by small diameter knitting technology.It was fabricated from polyglycolide(PGA)fibers and polylactide(PLA)fibers.The behavior of the scaffold during degradation in vitro and the morphology of the scaffold with cells were investigated.Results showed that the degradation of scaffold could be divided into three stages which could be named as "strength decrease stage","mass loss stage" and "quasi-stable stage" respectively.Cells were attached well both to the skin part and core part,and produced a lot of extracellular matrices. |
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| Keywords: | polyglycolide polylactide fiber scaffold degradation |
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