| 氟苯尼考/壳聚糖纳米微球的制备及其缓释性能 |
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| 引用本文： | 崔淑敏,宋美荣,王娟,聂立波,崔保安.氟苯尼考/壳聚糖纳米微球的制备及其缓释性能[J].河南大学学报(自然科学版),2010,40(1). |
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| 作者姓名： | 崔淑敏 宋美荣 王娟 聂立波 崔保安 |
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| 作者单位： | 1. 河南农业大学,理学院,郑州,450002
2. 河南农业大学,牧医工程学院,郑州,450002 |
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| 基金项目： | 国家十一五科技支撑计划资助项目 |
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| 摘 要： | 以三聚磷酸钠为交联剂,采用离子交联法制备了氟苯尼考/壳聚糖纳米微球,用激光粒度分析仪、扫描电镜表征了该纳米微球的微观结构和形态,并通过Zeta电位和红外光谱分析该载药纳米微球的形成机理.结果显示:当氟苯尼考与壳聚糖的质量分数为3∶5、壳聚糖与三聚磷酸钠的质量分数为5∶1时,氟苯尼考/壳聚糖纳米微球对氟苯尼考有较大的包封率(64.5%)和载药量(44.0%),并具有较好的缓释性能(45.5 h内释放79.2%),作为氟苯尼考的缓释剂型是可行的.药物释放曲线符合一级动力学方程.
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| 关 键 词： | 载药纳米微球 壳聚糖 氟苯尼考 制备 缓释 |
Preparation and Sustained Release Properties of Florfenicol/Chitosan Drug-Loaded Nanospheres |
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| CUI Shu-min,SONG Mei-rong,WANG Juan,NIE Li-bo,CUI Bao-an.Preparation and Sustained Release Properties of Florfenicol/Chitosan Drug-Loaded Nanospheres[J].Journal of Henan University(Natural Science),2010,40(1). |
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| Authors: | CUI Shu-min SONG Mei-rong WANG Juan NIE Li-bo CUI Bao-an |
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| Abstract: | Florfenicol(FF)/Chitosan(CS) drug-loaded nanospheres (FF-CM) was prepared by ionic crosslinking method with tripolyphosphate (TPP) as crosslinker. A study on these nanospheres' microstructures and configurations was conducted through observation of laser particle size analyzer, fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM). The results indicated that FF/CS drug-loaded nanospheres had a higher encapsulation rate (64.5%) and loading-drug rate (44.0%) when the mass ratio of FF to CS was 3∶5 and that of CS to TPP was 5∶1 and lower release rate (79.2% released in 45.5 h), so it is feasible for FF/CS drug-loaded nanospheres to be used as a sustained release form of florfenicol. The release curve of FF/CS drug-loaded nanospheres showed that the release processes of florfenicol followed a first-order kinetic model. |
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| Keywords: | drug-loaded nanospheres chitosan florfenicol preparation sustained release |
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