以端粒末端DNAs为靶分子的抗癌药物的研究进展

端粒末端G-四股螺旋DNAs可以抑制端粒酶的键合，进一步抑制癌细胞的生长和大量繁殖。因此，端粒DNAs已成为具有抗癌药物作用的靶分子，能键合并稳定G-四股螺旋DNAs的小分子化合物是潜在的抗肿瘤药物。设计和合成能特异性靶向G-四股螺旋DNAs并显著抑制端粒酶活性的配体成为当今抗癌药物研究的又一大热点。叙述了近年来以端粒G-四股螺旋DNAs为靶分子的抗癌药物设计、合成的最新进展。

Research Progress of the Anticancer Drug Taking an Endmost DNAs as Target Molecule

An endmost G four shares of spiral DNAs can suppress the key of an enzyme and growth and breed of the cancer cell further in a large amount . So endmost grains DNAs has already become target molecule with anticancer function, which can key amalgamate stability G four shares of spiral DNAs. Research progress of design and synthesis of the anticancer drug taking an endmost G four shares of spira DNAs as target molecule in recent years has been explained.