含氢化诺卜基叔胺氢卤酸盐的合成与抑菌活性研究

以5种含氢化诺卜基的叔胺分别与氯化氢、溴化氢、碘化氢反应,合成了14个氢化诺卜基叔胺的氢卤酸盐:二甲基氢化诺卜基胺盐酸盐(2a)、二甲基氢化诺卜基胺氢溴酸盐(2b)、二甲基氢化诺卜基胺氢碘酸盐(2c)、二乙基氢化诺卜基胺盐酸盐(2d)、二乙基氢化诺卜基胺氢溴酸盐(2e)、二正丙基氢化诺卜基胺盐酸盐(2f)、二正丙基氢化诺卜基胺氢溴酸盐(2g)、二正丙基氢化诺卜基胺氢碘酸盐(2h)、N-氢化诺卜基哌啶盐酸盐(2i)、N-氢化诺卜基哌啶氢溴酸盐(2j)、N-氢化诺卜基哌啶氢碘酸盐(2k)、N-氢化诺卜基吗啉盐酸盐(2l)、N-氢化诺卜基吗啉氢溴酸盐(2m)、N-氢化诺卜基吗啉氢碘酸盐(2n).对所合成的化合物进行了¹H NMR、¹³C NMR和LC-MS分析,表征了它们的结构.采用菌丝生长速率法测试了化合物2a、2b、2f、2h对5种植物病原菌生长的抑制率,结果表明它们均有较好的抑菌活性.当药液质量浓度为500 mg·L^-1时,2a、2b、2f、2h对烟草黑胫病菌的抑制率均在83%以上,其中2a的抑制率为100%; 对西瓜枯萎病菌和苦瓜尖孢镰刀病菌的抑制率均在65%以上,部分高达85%; 对轮枝镰刀病菌的抑制率均在75%以上.

The Synthesis and Antibacterial Activity of Hydrohalobyl Tertiary Amine Hydrohalide

Fourteen hydronopyl tertiary amine hydrohalide,namely dimethyl hydronopyl amine hydrochloride(2a),dimethyl hydronopyl amine hydrobromide(2b),dimethyl hydronopyl hydroiodate(2c),diethyl hydronopyl amine hydrochloride(2d),diethyl hydronopyl amine hydrobromide(2e),di-n-propyl hydronopyl amine hydrochloride(2f),di-n-propyl hydronopyl amine hydrobromide(2g),di-n-propyl hydronopyl hydroiodate(2h),N-hydronopyl pyfidine hydrochloride(2i),N-hydronopyl pyfidine hydrobromide(2j),N-hydronopyl pyfidine hydroiodate(2k),N-hydronorpyl morpholine hydrochloride(2l),N-hydronorpyl morpholine hydrobromide(2m),N-hydronorpyl morpholine hydroiodate(2n),are synthesized from five kinds of hydronopyl tertiary amines with hydrogen chloride,hydrogen bromide,and hydrogen iodide respectively.The structures of thefourteen targetcompounds are indentified by ¹H NMR,¹³C NMR and LC-MS analysis.The antifungal activities of four compounds(2a、2b、2f、2h)against Fusarium oxysporum,Colletotrichum acutatum,Fusarium verticillioides,Phytophthora nicotianae var. nicotianae Breda de Haan and Fusarium oxysporumf sp. momordicae are tested by using the mycelial growth rate method,the results show that the four compounds have good antifugal activity.At the mass concentration of 500 mg·L^-1.Their inhibition rates against Phytophthora nicotianae var nicotianae Breda de Haan are more than 83%,and the inhibition rate of 2a is 100%.Their inhibition rates against Fusarium oxysporum and Fusarium oxysporumf sp. momordicae are more than 65%(the highest is 85%).Their inhibition rates against Fusarium verticillioides are more than 75%.