| 1,4-双[(6-芳基)-1,2,4-三唑并[3,4-b]-[1,3,4]噻二唑-3-基]苯类衍生物的合成及抗癌活性研究 |
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| 引用本文： | 丁浩宇,李德江,代忠旭.1,4-双[(6-芳基)-1,2,4-三唑并[3,4-b]-[1,3,4]噻二唑-3-基]苯类衍生物的合成及抗癌活性研究[J].江西师范大学学报(自然科学版),2011,35(5):526-528. |
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| 作者姓名： | 丁浩宇 李德江 代忠旭 |
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| 作者单位： | 三峡大学化学与生命科学学院,湖北宜昌,443002 |
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| 基金项目： | 湖北省2010年高校产学研合作项目(C2010027)资助 |
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| 摘 要： | 对苯二甲羧酸酯化、肼解、成盐、环化成双-(4-氨基-5-巯基-1,2,4-三唑-3-基)苯(1),再与芳香羧酸(2a~2h)在相转移催化剂四丁基碘化铵和POCl3作用下,高产率制得8种1,4-双(6-芳基)-1,2,4-三唑并3,4-b]-1,3,4]噻二唑-3-基]苯类衍生物(3a~3h),并利用IR、1H NMR、MS和元素分析对目标化合物的结构进行了表征.用MTT方法评价了它们在体外对HepG-2、A549-1和231-2癌细胞株的体外生长抑制活性.结果表明,所合成的8个新化合物均具有潜在的体外抑制癌细胞生长活性,其中3a、3g与3h活性最强.
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| 关 键 词： | 双-1 2 4-三唑并[3 4-b]-[1 3 4]噻二唑 合成 抗癌活性 |
The Study on Synthesis and Anticancer Activities of 1,4-Bis[(6-Aryl)-1,2,4-Triazolo [3,4-b]-[1,3,4]Thiadiazole-3-Yl]Benzenes Derivatives |
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| DING Hao-yu,LI De-jiang,DAI Zhong-xu.The Study on Synthesis and Anticancer Activities of 1,4-Bis[(6-Aryl)-1,2,4-Triazolo [3,4-b]-[1,3,4]Thiadiazole-3-Yl]Benzenes Derivatives[J].Journal of Jiangxi Normal University (Natural Sciences Edition),2011,35(5):526-528. |
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| Authors: | DING Hao-yu LI De-jiang DAI Zhong-xu |
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| Institution: | DING Hao-yu,LI De-jiang,DAI Zhong-xu(College of Chemistry and Life Science,China Three Gorges University,Yichang Hubei 443002,China) |
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| Abstract: | The terephthaloylhydrazide were prepared by hydrazinolysis of the dimethyl terephthalate.The reaction of terephthaloyl with CS2/KOH in absolute ethanol gave potassium terephthaloyldithiocarbazate and then the reaction of potassium terephthaloyldithiocarbazate with hydrazine hydrate afforded 3-benzyloxyphenyl-4-amino-5mercapto-1,2,4-triazole(1).1,4-bis(6-aryl)-1,2,4-triazolo3,4-b]-1,3,4]thiadiazole-3-yl]benzene derivatives 3a-3h were accomplished with good yields by condensing bis-(4-amino-5-mercapto-1,2,... |
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| Keywords: | bis(4-amino-5-mercapto-1 2 4-triazol-3-yl)benzene synthesis anticancer activity |
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