| 新型三氮烯类化合物的合成与表征 |
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| 引用本文： | 雷强,张高鹏,赵丽,孙云鹤,薛倩倩,孟启,龙跃.新型三氮烯类化合物的合成与表征[J].郑州大学学报(自然科学版),2014(2):77-79. |
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| 作者姓名： | 雷强 张高鹏 赵丽 孙云鹤 薛倩倩 孟启 龙跃 |
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| 作者单位： | 郑州大学化学与分子工程学院,河南郑州450001 |
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| 基金项目： | 国家自然科学基金资助项目,编号J1210060;河南省科技攻关计划资助项目,编号0624420031;河南省基础研究基金资助项目,编号022463001. |
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| 摘 要： | 通过重氮盐的偶联反应以及Claisen-Schmidt反应合成了5个新型三氮烯类化合物,目标化合物的结构通过MS、1H-NMR、13C-NMR等方法得到证实.利用MTT法对所合成的化合物进行体外抗癌活性的筛选,发现5个新化合物均具有抗癌活性.
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| 关 键 词： | 三氮烯 氮偶联反应 合成 表征 |
Synthesis and Characterization of New Triazene Derivatives |
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| LEI Qiang,ZHANG Gao-peng,ZHAO Li,SUN Yun-he,XUE Qian-qian,MENG Qi,LONG Yue.Synthesis and Characterization of New Triazene Derivatives[J].Journal of Zhengzhou University (Natural Science),2014(2):77-79. |
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| Authors: | LEI Qiang ZHANG Gao-peng ZHAO Li SUN Yun-he XUE Qian-qian MENG Qi LONG Yue |
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| Institution: | 1.College of Chemistry and Molecular Engineering,Zhengzhou University,Zhengzhou 450001,China) |
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| Abstract: | Five new triazene derivatives were synthesized by nitrogen coupling reaction of the diazonium salt and Claisen-Schmidt reaction.These compounds were characterized by MS,1H-NMR and 13C-NMR.The results conformed well to expected structures.Five new compounds were sereened by MTT assay in vitro activity.It was discovered that all of these compounds had anti-cancer activity. |
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| Keywords: | triazene nitrogen coupling reaction synthesis characterization |
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