己二酸二甲酯的合成研究

以己二酸和无水甲醇为原料,一水合硫酸氢钠为催化剂合成了己二酸二甲酯,考察了醇酸摩尔比、催化剂用量、反应时间对酯化反应的影响,确定了合成己二酸二甲酯的最佳反应条件：n(己二酸)：n(无水甲醇)：n(一水合硫酸氢钠)=1：5：0．29,回流分水60 min,己二酸二甲酯收率达97．48％,纯度在98％以上。实验结果表明,一水合硫酸氢钠对合成己二酸二甲酯具有良好的催化活性。

Study on the Catalytic Synthesis of Dimethyl Adipate

Adipic acid and methanol were esterified to synthesize dimethyl adipate catalyzed by sodium bisulfate. The effects of the molar ratio of reactant, amount of catalyst and reaction time on the yield of dimethyl adipate were investigated. The optimized reaction conditions were established in which the yield and the purity of the ester could reach 97. 36% and 98% ,under the selected reaction conditions:n( adipic acid) :n(methanol):n( sodium bisulfate) = 1: 5: 0. 29 ,refluxing and water segregating for 60 min. The experimental results indicated that sodium bisulfate exhibited high catalytic activity for the esterification reaction.