| EIAV强毒株和疫苗株gp45的纯化及结晶比较 |
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| 引用本文： | 王建新,王敏,刘新奇.EIAV强毒株和疫苗株gp45的纯化及结晶比较[J].天津科技大学学报,2011(4):10-13,25. |
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| 作者姓名： | 王建新 王敏 刘新奇 |
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| 作者单位： | 天津科技大学生物工程学院;南开大学生命科学学院; |
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| 基金项目： | 国家973计划项目资助(2010CB911800); “艾滋病和病毒性肝炎等重大传染病防治”专项(2008ZX10001-010) |
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| 摘 要： | EIAV (equine infectious anemia virus)疫苗是世界唯一成功的慢病毒疫苗.通过对强毒株和疫苗株EIAV相关蛋白结构的比较研究,可以促进对其致弱过程及免疫机制的了解.gp45 (glycoprotein 45)是EIAV介导与宿主膜融合过程的关键蛋白.以EIAV强毒株LN40和疫苗株FDD...
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| 关 键 词： | EIAV 强毒株 疫苗株 gp45 结晶 |
Purification and Crystallization Comparison between EIAV gp45 of Virulent Strain and Vaccine Strain |
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| WANG Jian-xin,WANG Min,LIU Xin-qi.Purification and Crystallization Comparison between EIAV gp45 of Virulent Strain and Vaccine Strain[J].Journal of Tianjin University of Science & Technology,2011(4):10-13,25. |
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| Authors: | WANG Jian-xin WANG Min LIU Xin-qi |
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| Institution: | WANG Jian-xin1,WANG Min1,LIU Xin-qi2(1.College of Biotechnology,Tianjin University of Science & Technology,Tianjin 300457,China,2.College of Life Sciences,Nankai University,Tianjin 300071,China) |
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| Abstract: | EIAV(equine infectious anemia virus)vaccine is the only successful lentivirus vaccine in the world.By comparison studies of EIAV virulent strain and vaccine strain related protein structures,better realization of the attenuation process and immune mechanism can be achieved.The gp45(glycoprotein 45)is a key protein in mediating membrane fusion between EIAV and host cell.Taking EIAV virulent strain LN40 and vaccine strain FDDV13 as research subjects,the core structure of virulent strain and vaccine strain gp4... |
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| Keywords: | EIAV virulent strain vaccine strain gp45 crystallization |
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