| 茚酮化合物的合成研究 |
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| 引用本文： | 潘成学,蒋祥柳,张洪彬.茚酮化合物的合成研究[J].广西师范大学学报(自然科学版),2012,30(2):71-77. |
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| 作者姓名： | 潘成学 蒋祥柳 张洪彬 |
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| 作者单位： | 1. 广西师范大学化学化工学院,药用资源化学与药物分子工程国家重点实验室培育基地,广西桂林541004
2. 云南大学化学科学与工程学院,教育部自然资源药物化学重点实验室,云南昆明650091 |
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| 基金项目： | 国家973重大基础研究计划子项目 |
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| 摘 要： | 以芳香醛或邻苯二甲醚为原料,以分子内Friedel-Crafts酰基化、Nazarov环化、Pinacol重排等反应为主要合成策略,发展3条茚酮化合物的合成方法,共合成出8个茚酮化合物,所有产物的结构均经1H NMR、13C NMR表征和确认。合成方法具有原料价格低廉、实验操作简单、产率高等优点。
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| 关 键 词： | 茚酮化合物 Nazarov环化 Pinacol重排 合成 |
Synthesis of Indanones Derivatives |
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| PAN Cheng-xue
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JIANG Xiang-liu
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ZHANG Hong-bin.Synthesis of Indanones Derivatives[J].Journal of Guangxi Normal University(Natural Science Edition),2012,30(2):71-77. |
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| Authors: | PAN Cheng-xue JIANG Xiang-liu ZHANG Hong-bin |
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| Institution: | 1.State Key Laboratory Cultivation Base for the Chemistry and Molecular Engineering of Medicinal Resources,College of Chemistry and Chemical Engineering,Guangxi Normal University,Guilin Guangxi 541004,China;2.Key Laboratory of Medicinal Chemistry for Natural Resource,Ministry of Education,College of Chemistryand Chemical Engineering,Yunnan University,Kunming Yunnan 650091,China) |
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| Abstract: | Eight indanones derivatives were synthesized by three procedures for preparation of indanone derivatives starting from aromatic aldehydes or 1,2-dimethoxy-benzene with the Friedel-Crafts acylation,Nazarov cyclization or Pinacol rearrangement as the key steps in the synthesis,and the products were characterized and confirmed by 1 H NMR and 13 C NMR.The protocols possess the advantages of cheap material,simple operation and high yields. |
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| Keywords: | indanone derivatives Nazarov cyclization Pinacol rearrangement synthesis |
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