怀牛膝对未孕大鼠子宫平滑肌峰电活动的影响

在 Wistar未孕大鼠子宫角浆膜面上埋植一对 Ag- Ag Cl双极电极 ,腹腔注射不同剂量怀牛膝水煎剂后观察大鼠在体子宫平滑肌峰电活动的改变 .结果显示 :怀牛膝水煎剂显著增加未孕大鼠子宫肌电爆发波的最大振幅和峰面积 (P <0 .0 5 ) ,可延长爆发波持续时间和增加爆发波动作电位个数 (P <0 .0 5 ) ;怀牛膝水煎剂明显增大未孕大鼠子宫肌电单波的正波最大振幅、负波最大振幅和峰面积 (P <0 .0 5 ) .怀牛膝显著兴奋在体子宫平滑肌峰电活动的效应类似催产素 .

Action of Achyranthes bidentata Blume on the spike activity of the uterine smooth muscle in virgin rats

Female Wistar virgin rats were implanted with bipolar Ag AgCl electrodes on the serosa of uterine smooth muscle along longitudinal axis of uterus horn. After intraperitoneally injected water extracts of Achyranthes bidentata Blume in different doses, the changes of the myoelectric activity of uterus in rats were observed. Results show:Water extracts of Achyranthes bidentata Blume significantly increased the maximum amplitude and the peak area of bursts of action potentials ( P <0.05). It also prolonged the duration of bursts of action potentials and increased the number of action potential within bursts of action potentials ( P <0.05); Achyranthes bidentata Blume obviously increased the positive and the negative amplitude of individual action potential in uterine myoelectric activity in rats,and enlarged its peak area ( P <0.05).The exciting effect of Achyranthes bidentata Blume on the uterine smooth muscle was similar to that of oxytocin.