Study on synthesis and deplete harmful radical of cobalt prophyrins as the mimic of enzyme |
| |
| Authors: | Li Zao-ying Zhang Yue-ning Li Cong Feng Qing Xia Shu-zhen |
| |
| Institution: | (1) College of Chemistry and Environment Science, Wuhan University, 430072 Wuhan, China;(2) Department of Chemistry, Tongji Medical University, 430030 Wuhan, China |
| |
| Abstract: | The four cobalt porphyrins Co (3, 4, 5-MeO-TPP) (1); Co (TTP) (2); Co (4-Cl-TPP) (3); Co (4-HSO3-TPP) (4)] were synthesized and considered as two mimic of superoxide dismutaes (SOD) and catalase (CAT). The catalytic efficiency
of them on deplete the harmful radical have been proved using riboflavin-methionine photoreduction method in the concentration
range of 10−6∼10−5 mol/L. The catalytic efficiency of them at decomposing H2O2 has been performed by spectrophotometer. The percentage of decomposing H2O2 while the increasing the concentration of the imitating compounds. The lipid peroxidation produced in liver homogenated of
mice was determined by spectrophotometer detecting the content of MDA. |
| |
| Keywords: | cobalt porphyrin synthesis superoxide dismutaes catalase two functional mimic of enzyme |
| 本文献已被 SpringerLink 等数据库收录！ |
