SV40 transformed fibroblasts recognize the same 140 kD fibronectin chemotactic fragment as non-transformed cells |
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Authors: | A Albini G Allavena H Richter B F Pontz S Parodi L Santi |
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Institution: | (1) Istituto Nazionale per la Ricerca sul Cancro, I-16132 Genova, Italy;(2) Max-Planck-Institut für Biochemie, D-8033 Martinsried, Germany;(3) Kinderklinik der Universität, D-6500 Mainz, Germany |
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Abstract: | Summary SV40 virus-transformed human embryonal fibroblasts show an enhanced chemotactic response to the glycoprotein fibronectin. However, they recognize the same chemotactic active region as non-transformed fibroblasts. The result suggests that an enhancement of chemotaxis by fibroblasts which have been transformed with Simian Virus 40 is due not to the utilization of further chemotactic domains in the molecule, but to an increased sensitivity of the cells to the chemoattractant. |
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Keywords: | Fibronectin domains chemotaxis SV40 fibroblasts |
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