| 高压静电法制备蛋白类药物微胶囊 |
| |
| 引用本文： | 高建成,李保国,丁志华,李凌云.高压静电法制备蛋白类药物微胶囊[J].上海理工大学学报,2004,26(2):107-110. |
| |
| 作者姓名： | 高建成 李保国 丁志华 李凌云 |
| |
| 作者单位： | 上海理工大学,动力工程学院,上海,200093 |
| |
| 摘 要： | 探索了将高压静电法用于制备蛋白药的可能性，选用牛血清白蛋白为芯材，海藻酸钙-壳聚糖为壁材进行了微胶囊化研究，并对芯材／壁材的比例、壳聚糖浓度及微胶囊释放情况进行了研究．结果表明，此方法制备的牛血清白蛋白微胶囊不但形状圆整、粒径分布均匀，而且有较高的包封率和载药量，是一种很好的制备蛋白类药物微胶囊的方法．
|
| 关 键 词： | 微胶囊 高压静电法 壳聚糖 牛血清白蛋白 |
| 文章编号： | 1007-6735(2004)02-0107-04 |
| 修稿时间： | 2003年10月31 |
Studies on the protein microcapsule prepared by high-voltage electrostatic field |
| |
| GAO Jian-cheng,LI Bao-guo,DING Zhi-hu,LI Ling-yun.Studies on the protein microcapsule prepared by high-voltage electrostatic field[J].Journal of University of Shanghai For Science and Technology,2004,26(2):107-110. |
| |
| Authors: | GAO Jian-cheng LI Bao-guo DING Zhi-hu LI Ling-yun |
| |
| Abstract: | A high voltage static electricity system is applied to microencapsuling proteins.The experiment of the drug microcapsule with bovine serum albumin (BSA) as drug and sodium alginate as carrier is carried out.The parameters in the experiment such as the ratio between core and carrier,the concentration of chitosan and the release of drug in microcapsule are studied in detail.Under the optimal conditions,the drug microcapsule is spherical and uniform with high encapsulation efficiency and drug loading. |
| |
| Keywords: | microcapsule high voltage electrostatic field chitosan bovine serum albumin |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
| 点击此处可从《上海理工大学学报》浏览原始摘要信息 |
| 点击此处可从《上海理工大学学报》下载免费的PDF全文 |
