| Comparative study of microstructural remodification to porous β-TCP and HA in rabbits |
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| 引用本文： | SUN Jiao,SHEN QingYi & LU JianXi Ninth People’s Hospital,School of Medicine,Shanghai Key Laboratory of Stomatology,Shanghai Biomaterials Research & Test Center,Shanghai Jiaotong University,Shanghai ,China.Comparative study of microstructural remodification to porous β-TCP and HA in rabbits[J].中国科学通报(英文版),2009,54(17):2962-2967. |
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| 作者姓名： | SUN Jiao SHEN QingYi & LU JianXi Ninth People’s Hospital School of Medicine Shanghai Key Laboratory of Stomatology Shanghai Biomaterials Research & Test Center Shanghai Jiaotong University Shanghai China |
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| 作者单位： | Ninth People＇s Hospital, School of Medicine, Shanghai Key Laboratory of Stomatology, Shanghai Biomaterials Research ＆ TestCenter, Shanghai Jiaotong University, Shanghai 200023, China |
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| 基金项目： | Supported by the Shanghai Sci-Tech Committee Foundation (Grant No. 08DZ2291600);;Shanghai Leading Academic Discipline Project (Grant No. S30206) |
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| 摘 要： | To assess the remolding ability of repaired bone in hydroxyapatite （HA） and β-calcium phosphate （β-TCP） scaffold, two 75% porosity bioceramics with the same three-dimensional geometry were implanted into femoral condyles of rabbits. Histological and micro-computed tomography （micro-CT） results demonstrated abundant new bone formation in the porous HA scaffold along with indistinctive scaffold degradation. Results also indicated that scaffold resorption in the β-TCP group, which was followed by a replacement with newly formed bone, was significantly higher than that in the HA group. The crosslinking trabeculae remodeled from the mixtures of the newly formed bone and β-TCP scaffold remnants might be helpful to promoting even loading and reducing stress. The bone remodeling pattern resulted from bone formation and scaffold resorption was significantly different for the two bioceramics. The results demonstrated that the 75% porous β-TCP was more suitable for new bone remodification than HA scaffold.
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| 关 键 词： | TCP 多孔 计算机断层扫描 微观 兔 生物陶瓷 羟基磷灰石 三维几何 |
| 收稿时间： | 2008-11-30 |
| 修稿时间： | 2009-04-08 |
Comparative study of microstructural remodification to porous β-TCP and HA in rabbits |
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| Jiao Sun,QingYi Shen,JianXi Lu.Comparative study of microstructural remodification to porous β-TCP and HA in rabbits[J].Chinese Science Bulletin,2009,54(17):2962-2967. |
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| Authors: | Jiao Sun QingYi Shen JianXi Lu |
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| Institution: | Ninth People’s Hospital, School of Medicine, Shanghai Key Laboratory of Stomatology, Shanghai Biomaterials Research &|Test Center, Shanghai Jiaotong University, Shanghai 200023, China |
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| Abstract: | To assess the remolding ability of repaired bone in hydroxyapatite (HA) and β-calcium phosphate (β-TCP) scaffold, two 75% porosity bioceramics with the same three-dimensional geometry were im-planted into femoral condyles of rabbits. Histological and micro-computed tomography (micro-CT) re-sults demonstrated abundant new bone formation in the porous HA scaffold along with indistinctive scaffold degradation. Results also indicated that scaffold resorption in the β-TCP group, which was followed by a replacement with newly formed bone, was significantly higher than that in the HA group. The crosslinking trabeculae remodeled from the mixtures of the newly formed bone and β-TCP scaffold remnants might be helpful to promoting even loading and reducing stress. The bone remodeling pat-tern resulted from bone formation and scaffold resorption was significantly different for the two bio-ceramics. The results demonstrated that the 75% porous β-TCP was more suitable for new bone re-modification than HA scaffold. |
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| Keywords: | &beta -tricalcium phosphate (&beta -TCP) hydroxyapatite (HA) bone remodeling biodegradation histomorphometry |
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