| 芳姜黄酮和姜烯衍生物的合成及抗生育活性初探 |
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| 引用本文： | 耿娓琴,陈钟瑛,严秉淳.芳姜黄酮和姜烯衍生物的合成及抗生育活性初探[J].华东理工大学学报(自然科学版),1990(1). |
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| 作者姓名： | 耿娓琴 陈钟瑛 严秉淳 |
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| 作者单位： | 华东化工学院精细化工系，华东化工学院精细化工系，华东化工学院精细化工系 四川重庆重庆医科大学 |
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| 摘 要： | 叙述了四个倍半萜类衍生物——芳姜黄酮(Ⅰ)、对甲氧基芳姜黄酮(Ⅱ)、(-)-异丙水芹烯(Ⅲ)、(-)-水芹烯羧酸乙酯(Ⅳ)的合成及结构确证。(Ⅱ～Ⅳ)未见文献报道。初步药理筛选结果表明:(Ⅰ)抗生育活性不理想;(Ⅲ)具有一定的抗生育活性。
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| 关 键 词： | 倍半萜 合成 抗生育活性 水芹烯 姜烯 |
Synthesis of Sesquiterpene Ar-Turmerone and Optically Active Zingiberene Derivatives and Exploration of Their Antifertility Effect |
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| Geng Weiqin,Chen Zhongying Yan Bingchun.Synthesis of Sesquiterpene Ar-Turmerone and Optically Active Zingiberene Derivatives and Exploration of Their Antifertility Effect[J].Journal of East China University of Science and Technology,1990(1). |
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| Authors: | Geng Weiqin Chen Zhongying Yan Bingchun |
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| Institution: | Department of Fine Chemicals |
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| Abstract: | The synthesis of four compounds, viz., ar-turmerone, (-)-isopropyl phellandrene, (-)-ethoxy carbonyl phellandrene and methoxy ar-turmerone, and the identification of their chemical structures are described. The preliminary pharmacological test data indicate that the antifertility effect of ar-turmerone is unsatisfactory and (-)-isopropyl phellandrene is antifertilely effective to a certain extent. The antifertility effect of (-)-ethoxy carbonyl phellandrene and methoxy ar-turmerone is being assayed.As far as authors know, the compounds of (-)-isopropyl phellandrene, (-)-ethoxy carbonyl phellandrene and methoxy ar-turmerone have not been reported in the literature. |
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| Keywords: | sesquiterpene synthesis ar-turmerone phellandrene zingiberene |
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