| 氯化钠促进溶菌酶聚集机制的分子动力学研究 |
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| 引用本文： | 关婧,李辉,邹志远,何剑为,宋有涛.氯化钠促进溶菌酶聚集机制的分子动力学研究[J].东北师大学报(自然科学版),2011,43(3):117-121. |
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| 作者姓名： | 关婧 李辉 邹志远 何剑为 宋有涛 |
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| 作者单位： | 辽宁大学生命科学学院,辽宁沈阳,110036 |
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| 基金项目： | 国家自然科学基金资助项目(30970152); 辽宁省教育厅优秀人才基金资助项目(2009R26) |
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| 摘 要： | 氯化钠能够在一定的条件下促进溶菌酶发生聚集,但其具体的作用机制目前还尚不明确.采用分子动力学模拟的方法研究了鸡溶菌酶单体在含500 mmol/L NaCl和不合NaCl两种体系中的结构变化.模拟的结果表明:NaCl能够使溶菌酶聚集关键区域(40～110位残基)内二硫键cys76-cys94的结合强度减弱,同时破坏了该区...
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| 关 键 词： | 溶菌酶 氯化钠 淀粉样聚集 分子动力学模拟 |
Mechanism study of sodium chloride on lysozyme aggregation investigated by molecular dynamics simulation |
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| GUAN Jing,LI Hui,ZOU Zhi-yuan,HE Jian-wei,SONG You-tao.Mechanism study of sodium chloride on lysozyme aggregation investigated by molecular dynamics simulation[J].Journal of Northeast Normal University (Natural Science Edition),2011,43(3):117-121. |
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| Authors: | GUAN Jing LI Hui ZOU Zhi-yuan HE Jian-wei SONG You-tao |
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| Institution: | GUAN Jing,LI Hui,ZOU Zhi-yuan,HE Jian-wei,SONG You-tao(College of Life Sciences,Liaoning University,Shenyang 110036,China) |
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| Abstract: | Sodium chloride(NaCl) could induce lysozyme aggregation under some conditions,but the detail mechanism has been poorly understood.In this study,performed 10 ns molecular dynamic simulations to investigate the structure changes of chicken lysozyme monomer when treated with 500 mmol/L NaCl.The simulation results indicated that NaCl could weaken the disulfide bond cys76-cys94 as well as the hydrogen bonding network in the aggregation critical region,which might lead instability of the lysozyme structure.In add... |
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| Keywords: | lysozyme sodium chloride amyloid aggregation molecular dynamics simulation |
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