| 酵母生产麦角固醇流加培养过程的优化 |
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| 引用本文： | 史新元,戚以政,谭天伟.酵母生产麦角固醇流加培养过程的优化[J].北京化工大学学报(自然科学版),2001,28(2):1-3,8. |
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| 作者姓名： | 史新元 戚以政 谭天伟 |
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| 作者单位： | 北京化工大学化学工程学院, 北京 100029 |
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| 基金项目： | 国家科技攻关项目;96-C03-01-02; |
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| 摘 要： | 对酿酒酵母生产麦角固醇的流加培养过程进行了研究,提出了以比生长速率为控制参数的流加方案,并以生物量、麦角固醇比生产速率、麦角固醇含量等因素为依据确定了该发酵体系的最优培养参数。在最优方案下,生物量可达42g/L,麦角固醇含量达326g(每100g干菌体中)
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| 关 键 词： | 酵母 麦角固醇 比生长速度 维生素D2前体 优化控制 流加培养 发酵法生产 |
| 收稿时间： | 2000-09-22 |
The study on optimal control of yeast fed-batch fermentation for ergosterol production |
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| SHI Xin,yuan,QI Yi,zheng,TAN Tian,wei.The study on optimal control of yeast fed-batch fermentation for ergosterol production[J].Journal of Beijing University of Chemical Technology,2001,28(2):1-3,8. |
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| Authors: | SHI Xin yuan QI Yi zheng TAN Tian wei |
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| Institution: | College of Chemical Engineering , Beijing University of Chemical Technology , Beijing 100029 , China |
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| Abstract: | In this paper,fed batch culture of ergosterol from Saccharomyces cerevisiae was studied. The optimal strategy by controlling the specific growth rate was suggested. On the basis of biomass, ergosterol content and the specific production rate of ergosterol,the optimal culture paramrters of ergosterol fermentation by fed batch were obtained. In the best plan,biomass reaches to 42 g/L and ergosterol content reachs to 3 26 g in 100 g dry cell. |
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| Keywords: | yeast ergosterol specific growth rate specific production rate |
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