| 3-O-甲基-4，6-O-苯亚甲基-N-（2-吡啶基）-α-D-葡萄糖的合成研究 |
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| 引用本文： | 沈超,赵卿,章鹏飞.3-O-甲基-4，6-O-苯亚甲基-N-（2-吡啶基）-α-D-葡萄糖的合成研究[J].杭州师范学院学报(自然科学版),2008,7(6):449-452. |
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| 作者姓名： | 沈超 赵卿 章鹏飞 |
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| 作者单位： | 杭州师范大学材料与化学化工学院,浙江杭州310036 |
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| 基金项目： | 浙江省自然科学基金人才(省杰出青年团队)资助项目 |
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| 摘 要： | 研究了以α-D-葡萄糖为原料，经异丙叉基保护、甲基化、苯亚甲基化等步骤合成了3-O-甲基-4，6-O-苯亚甲基-N-（2-吡啶基）-α-D-葡萄糖，产物经质谱、核磁共振谱及红外光谱对其进行了结构表征分析。N-杂环取代的糖类化合物是一种重要的医药和有机合成中间体，该类化合物将在合成糖基、核苷类似物、杂环化合物、糖多肽等具有潜在药理活性的化合物中具有广阔的应用前景．
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| 关 键 词： | D-葡萄糖 3-O-甲基-4 6-O-苯亚甲基-N-(2-吡啶基)-α-D-葡萄糖 医药和有机中间体 合成 |
The Research on the Synthesis of 3-O-methyl-4, 6-O-benzylidene-N-(2-pyridyl)-α-D-glucopyranosylamine |
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| SHEN Chao,ZHAO Qing,ZHANG Peng-fei.The Research on the Synthesis of 3-O-methyl-4, 6-O-benzylidene-N-(2-pyridyl)-α-D-glucopyranosylamine[J].Journal of Hangzhou Teachers College(Natural Science),2008,7(6):449-452. |
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| Authors: | SHEN Chao ZHAO Qing ZHANG Peng-fei |
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| Institution: | (College of Material and Chemistry ＆ Chemical Engineering, Hangzhou Normal University, Hangzhou, 310036) |
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| Abstract: | The paper researches on a novel method for the synthesis of 3-O-methyl-4, 6-O-benzylidene-N-（g-pyridyl）-α-D-glucopyranosylamine by using D-glucose as the starting material through multi-step and the product is synthesized and characterized by MS, NMR, IR first time. The 3-O-methyl-4, 6-O-benzylidene-N-（2-pyridyl）-α-D-glucopyranosylamine is an important pharmaceutical and organic intermediate which could serve as versatile intermediates for the synthesis of glycosyl derivatives such as thioureas, nucleosides, heterocyclic compounds, polypeptide, etc. |
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| Keywords: | D-glucose 3-O-methyl-4 6-O-benzylidene-N-（2-pyridyl）-a-D-glucopyranosyla-mine pharmaceutical andorganic intermediate synthesis |
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