| 氮支套索冠醚V．N－氨乙基单氮杂冠醚合成中氨基的保护研究 |
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| 引用本文： | 秦圣英,刘学明,芦晓霞,张小荣.氮支套索冠醚V．N－氨乙基单氮杂冠醚合成中氨基的保护研究[J].四川大学学报(自然科学版),1996(1). |
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| 作者姓名： | 秦圣英 刘学明 芦晓霞 张小荣 |
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| 作者单位： | 湖北工学院食品工业系 |
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| 摘 要： | 研究了一种新的氮支套素冠醚侧链上氨基的保护和脱保护基方法，结果表明，由过量乙二胺与对甲苯磺酰氯反应得到的单保护乙二胺（Ｎ－对甲苯磺酰基乙二胺４ａ），经Ｎ－烷基化环化反应，然后在氢化铝锂存在下脱除保护基，即可制得最佳产率的Ｎ－（２－氨基已基）单氮杂－１２－冠－４（１）．
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| 关 键 词： | 套索冠醚，单氮杂冠醚，氨基，保护基，合成 |
N-PIVOT LARIAT CROWN ETHER V.STUDY ON PROTECTION FOR AMINO-GROUP IN THE SYNTHESIS OF N-(2-AMINOETHYL)MONOAZACROWN ETHER |
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| Qin Shengying,Liu Xueming,Lu Xiaoxia Zhang Xiaorong.N-PIVOT LARIAT CROWN ETHER V.STUDY ON PROTECTION FOR AMINO-GROUP IN THE SYNTHESIS OF N-(2-AMINOETHYL)MONOAZACROWN ETHER[J].Journal of Sichuan University (Natural Science Edition),1996(1). |
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| Authors: | Qin Shengying Liu Xueming Lu Xiaoxia Zhang Xiaorong |
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| Institution: | Department of Chemistry |
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| Abstract: | Both the protection and deprotective group methods for the amino-group on side chain of a new N-pivot lariat crown ether were studied comparatively.It has ben found that N-(2-aminoethyl)monoaza-12-crown-4 could be prepared in the most excellent yield via the N-cycloalkylation of monoprotected ethylenedtamine (N-tosylethylenodimine 4a),which was obtained by the reaction of excess ethylendamine with tosyl chloride,and following deprotective group(Ts)in the presence of lithium aluminium hydride. |
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| Keywords: | lariat crown ether monoazacrown ether amino-group protective group synthesis |
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