| 1,3,4-三苯基吡唑并喹啉类衍生物的微波合成 |
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| 引用本文： | 胡杨,刘毅锋,张娟,张亚洲,毕芳琳.1,3,4-三苯基吡唑并喹啉类衍生物的微波合成[J].西北大学学报,2012(2):241-244. |
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| 作者姓名： | 胡杨 刘毅锋 张娟 张亚洲 毕芳琳 |
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| 作者单位： | 西北大学应用化学研究所 |
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| 基金项目： | 陕西省自然科学基金资助项目(2011JM2114) |
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| 摘 要： | 目的对吡唑3,4-b]喹啉类化合物的合成方法进行研究。方法用微波辐射,在无溶剂条件下,以对甲苯磺酸为催化剂,使1,3-二苯基吡唑啉酮、苯甲醛和取代苯胺进行反应,反应时间为8～12 min,合成出了目标产物。结果合成出了一系列吡唑3,4-b]喹啉类化合物,用元素分析、IR和1HNMR对所合成的化合物进行了表征,产率可达到52%～62%。结论该方法操作简单反应时间短产率较高,对环境友好。
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| 关 键 词： | 1 3-二苯基吡唑啉-5-酮 苯甲醛 取代苯胺 微波辐射 合成 吡唑喹啉 |
Synthesis of 1,3,4-triphenyl-1H-pyrazolo quinline derivates under microwave irradation |
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| HU Yang,LIU Yi-feng,ZHANG Juan,ZHANG Ya-zhou,Bi Fang-lin.Synthesis of 1,3,4-triphenyl-1H-pyrazolo quinline derivates under microwave irradation[J].Journal of Northwest University(Natural Science Edition),2012(2):241-244. |
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| Authors: | HU Yang LIU Yi-feng ZHANG Juan ZHANG Ya-zhou Bi Fang-lin |
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| Institution: | (Institute of Applied Chemistry,Northwest University,Xi′an 710069,China) |
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| Abstract: | Aim To reserch the method for microwave-assisted synthesis of 1,3,4-triphenyl-1-H-1-pyrazoloquinolines.Methods Under solvent-free condition,using p-TSOH as catalyst,the reaction of p-toluidine,benzaldehyde and 1,3-diphenyl-1H-pyrazol-5(4H)-one were processed under microwavre radiation for 12 minutes to give the coressponding 1,3,4-triphenyl-1H-pyrazoloquinolines.Results The structure of the compounds was confirmed by IR,1H-NMR and elentary analysis.The yield of target compounds is 52%~62%.Conclusion The method is mild,simple,environment-friendly and available for synthesis of 1,3,4-triphenyl-1H-pyrazoloquinolines in good yields without use of solvent. |
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| Keywords: | 1 3-diphenyl-2-pyrazolin-5-one benzaldehyde arylamine microwave radiation synthesis 1 3 4-triphenyl-1H-pyrazoloquinolines |
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