| 邻卤苯乙酸合成方法的改进 |
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| 引用本文： | 蔡可迎,丁明洁,宗志敏,魏贤勇.邻卤苯乙酸合成方法的改进[J].湖北大学学报(自然科学版),2007,29(1):82-84,88. |
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| 作者姓名： | 蔡可迎 丁明洁 宗志敏 魏贤勇 |
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| 作者单位： | 徐州教育学院化学系，中国矿业大学化工学院，中国矿业大学化工学院，中国矿业大学化工学院 江苏徐州221006，中国矿业大学化工学院，江苏徐州221008，江苏徐州221008，江苏徐州221008，江苏徐州221008 |
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| 摘 要： | 以NaOH溶液快速沉淀CuCl2和AlCl3的混合溶液制备了催化剂CuO-Al2O3.在20%NaOH水溶液中,以CuO-Al2O3催化水合肼还原邻硝基苯乙酸得到邻氨基苯乙酸,经重氮化和卤置换反应得到邻卤苯乙酸,收率65%~73%.总收率为40%~45%.
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| 关 键 词： | 邻卤苯乙酸 邻硝基苯乙酸 邻硝基甲苯 合成 |
| 文章编号： | 1000-2375（2007）01-0082-03 |
| 收稿时间： | 2006-05-19 |
| 修稿时间： | 2006-05-19 |
Improved synthesis of o-halophenylacetic acid |
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| CAI Ke-ying,DING Ming-jie,ZONG Zhi-min,WEI Xian-yong.Improved synthesis of o-halophenylacetic acid[J].Journal of Hubei University(Natural Science Edition),2007,29(1):82-84,88. |
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| Authors: | CAI Ke-ying DING Ming-jie ZONG Zhi-min WEI Xian-yong |
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| Institution: | 1. Department of Chemistry, Xuzhou Education College, Xuzhou 221006, China; 2.School of Chemical Engineering, China University of Mining and Technology, Xuzhou 221008, China |
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| Abstract: | o-Nitrophenylacetic acids were synthesized in ca.62% by C2H5ONa-catalyzed condensation of o-nitrotoluene with diethyl oxalate and subsequently by hydrolysis,oxidation with H2O2 and acidation with HCl.They were further converted to o-halophenylacetic acids by CuO-Al2O3-catalyzed reduction with hydrazine hydrate in 20% NaOH aqueous solution,diazonation and substitution with haloatoms in 65%~73% yields.The overall yield is about 40%~45%. |
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| Keywords: | o-halophenylacetic acid o-nitrophenylacetic acid o-nitrotoluene synthesis |
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