| 双二茂铁基酰胺化合物的合成与表征 |
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| 引用本文： | 张成路,李元东,王利东,王杨,申洪江,广东.双二茂铁基酰胺化合物的合成与表征[J].辽宁师范大学学报(自然科学版),2009,32(1):87-89. |
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| 作者姓名： | 张成路 李元东 王利东 王杨 申洪江 广东 |
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| 作者单位： | 辽宁师范大学化学化工学院,辽宁,大连,116029 |
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| 摘 要： | 以L-缬氨酸和二茂铁为原料,经过6步反应合成了双二茂铁基酰胺化合物8.一方面,以L-缬氨酸为原料,利用NaBH4将其还原为L-缬氨醇;另一方面,以二茂铁为原料,首先合成中间体二茂铁甲酸4,然后将4转化为二茂铁甲酰氯,后者直接与L-缬氨醇在Et3N存在下进行反应得到化合物6.将6转换为氯代产物7,化合物7不经分离直接与对甲苯磺酰胺的钠盐进行反应合成目标产物8,利用IR、NMR等结构表征,表明经该法成功合成了目标产物.
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| 关 键 词： | 双二茂铁基酰胺化合物 合成 表征 |
Synthesis and characterization of diferrocenyl acidamide |
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| ZHANG Cheng-lu,LI Yuan-dong,WANG Li-dong,WANG Yang,SHEN Hong-jiang,GUANG Dong.Synthesis and characterization of diferrocenyl acidamide[J].Journal of Liaoning Normal University(Natural Science Edition),2009,32(1):87-89. |
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| Authors: | ZHANG Cheng-lu LI Yuan-dong WANG Li-dong WANG Yang SHEN Hong-jiang GUANG Dong |
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| Institution: | (School of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian 116029, China) |
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| Abstract: | Diferrocenyl acidamide 8 was synthesized through six steps starting from L-valine and ferro- cene. First L-valinol was obtained by reduction of L-valine using NaBH4 as reducing agent. On the other hand, ferrocenyl acid 3 was synthesized and then transferred into acyl chloride. The later was directly reacted with L-valinol to afford compound 6 in the condition of Ets N. Compound 8 was finally obtained by transformation of compound 6 into the chloride 7 which needs not be separated coud dcrectly reacted with p-CH3PhSO2NHNa. IR and NMR spectra were used to confirm the structure. |
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| Keywords: | diferroeenyl acidamide synthesis charaeterazation |
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